Medication info
Silo-Duo Extended Release Tablet 200/10 mg (Cilostazol, Rosuvastatin)

Silo-Duo Extended Release Tablet 200/10 mg (Cilostazol, Rosuvastatin)

Prescription medicationTablet경구
Ingredient · strength
Cilostazol›80mg / 1 tabletRosuvastatin Calcium›10.4mg / 1 tablet
Manufacturer / importer
한국유나이티드제약(주)
Appearance
Pink oval extended-release film-coated tablet
Packaging
Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle
Approval status
Active

MFDS item code 202502257 · Approved 2025.08.27 · Insurance code 644309840

Summary

Main use
Improvement of atherosclerosis and peripheral vascular disease
Who takes it
Adults
Adult dose
Take 1 tablet once a day on an empty stomach, avoiding meals. Do not crush or chew this medication, but swallow the whole tablet.

Ingredients

Manufacturer
한국유나이티드제약(주)

Efficacy & effects

Improvement of atherosclerosis and peripheral vascular disease

  • Chronic arterial occlusive disease due to atherosclerosis
  • obstructive arteriosclerosis
  • diabetic peripheral vascular disease
View approved original text

If patients are taking Rosuvastatin and Cilostazol for chronic arterial occlusive disease due to atherosclerosis and diabetic peripheral vascular disease, these two medications help control blood cholesterol levels and improve blood circulation. When considering alternative medications, it is important to select lipid-lowering agents and blood flow enhancers with the same effects. For example, atorvastatin, another statin, can be used instead of Rosuvastatin, and pentoxifylline, which has blood flow improvement effects, can be considered as an alternative to Cilostazol. However, any changes to medications should be discussed with a specialist to carefully assess the patient's condition and risk of side effects. The combination therapy should be individualized, prioritizing the maintenance of therapeutic efficacy and safety.

How to take

Adult dose

Take 1 tablet once a day on an empty stomach, avoiding meals. Do not crush or chew this medication, but swallow the whole tablet.

Precautions

This medication contains two components that improve blood circulation and control cholesterol levels. Firstly, this medication should be used with caution in patients with heart disease or experiencing angina symptoms. Increased heart rate may lead to symptoms of angina, such as chest pain, so it is essential to discuss these symptoms with a physician. Additionally, patients with bleeding tendencies or at high risk for bleeding, patients with congestive heart failure, patients with severe liver dysfunction, and patients with muscular disorders should not take this medication. Pregnant or breastfeeding women, as well as women of childbearing age who do not use appropriate contraception, should also avoid this medication. This medication may affect blood coagulation, so patients taking anticoagulants or antiplatelet agents must consult a physician before taking it. Women who are menstruating should also be cautious due to the risk of bleeding. Patients with weak liver function, diabetes, uncontrolled high blood pressure, or arrhythmias must use this medication carefully. If symptoms such as muscle pain, muscle weakness, fatigue, or fever occur while taking this medication, it is crucial to notify medical personnel immediately and, if necessary, blood tests should be performed to check for muscle damage. Taking this medication with food may increase blood concentration and the risk of side effects, so it is recommended to take it on an empty stomach, and to avoid high-fat meals. Caution is advised when driving or operating machinery, as dizziness may occur. Furthermore, this medication can interact with various drugs, so if other medications are being taken, it is essential to inform a physician or pharmacist and seek advice. Women who are pregnant or planning to become pregnant should avoid taking this medication, and if pregnancy occurs during treatment, it should be stopped immediately. Breastfeeding women should also avoid taking this medication and should stop breastfeeding if taking it. For elderly patients, caution is required due to potentially reduced physical function. In cases of overdose, severe headache, diarrhea, hypotension, rapid heartbeat, and arrhythmias may occur, so immediate medical attention is necessary. Finally, keep this medication out of the reach of children, and avoid transferring it to other containers.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, hematological abnormalities (pancytopenia, agranulocytosis, thrombocytopenia, aplastic anemia), jaundice, severe skin adverse reactions (Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms), bleeding tendencies (intracranial hemorrhage, pulmonary hemorrhage, gastrointestinal bleeding), interstitial pneumonia, congestive heart failure, myocardial infarction, angina, ventricular tachycardia, acute kidney failure

Mild side effects

  • Headache
  • dizziness
  • diarrhea
  • constipation
  • abdominal pain
  • dry mouth
  • indigestion
  • upper abdominal pain
  • intracranial aneurysm
  • polyneuropathy
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  • back pain
  • limb pain
  • myalgia
  • myositis
  • osteoarthritis
  • spinal stenosis
  • weakness
  • fever
  • dryness
  • cough
  • exertional dyspnea
  • obstructive sleep apnea syndrome
  • increased blood creatine phosphokinase
  • increased blood creatinine
  • elevated aspartate aminotransferase
  • palpitations

Not everyone experiences these, and they can vary from person to person.

Storage

Store this medication in a sealed container to prevent air from entering, and keep it at a temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain its effectiveness and ensures safe use.

Appearance and packaging

Appearance

Pink oval extended-release film-coated tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.