Empagliflozin and Metformin Extended-Release Tablets 5/1000 mg (Empagliflozin, Metformin)

Adult dose

This medication should be taken once daily in the evening with meals to reduce gastrointestinal adverse reactions associated with metformin. The extended-release formulations of this medication 10/1000 mg or 25/1000 mg should be taken once daily, with one tablet per dose. Patients taking the extended-release 5/1000 mg or 12.5/1000 mg should take two tablets simultaneously once daily. Regarding the use of metformin.

This medication is used in the treatment of diabetes and works with two components to control blood sugar. Rare but serious side effects such as lactic acidosis may occur while taking this medication, so caution is advised, especially in patients with impaired renal function or cardiovascular disease. Additionally, taking this medication with insulin or sulfonylureas may increase the risk of hypoglycemia, so blood sugar levels must be monitored closely. Patients with moderate to severe renal impairment, acute renal problems, severe infections, heart failure, or acute myocardial infarction should not use this medication. Before and after tests using iodinated contrast agents, the intake of this medication should be temporarily suspended due to the risk of renal function deterioration and lactic acidosis, resuming only after renal function is confirmed to be normal. It is also advised that women who are pregnant or may become pregnant, patients with severely impaired liver function, and those in significantly poor nutritional status should avoid using this medication. While taking this medication, side effects such as hypoglycemia, urinary tract infections, genital infections, increased urination, gastrointestinal disorders (nausea, vomiting, diarrhea, etc.), hepatic dysfunction, skin rash, and others may occur, and any abnormal symptoms should be discussed with a healthcare provider. Particularly, elderly patients or those at risk of fluid loss should pay attention to dehydration or hypotension and must have their renal function regularly examined. Taking this medication along with alcohol increases the risk of lactic acidosis, so alcohol consumption should be avoided. The tablets should be swallowed whole and not chewed or crushed; the tablet coating may appear in stool but this is normal. It is important to regularly check blood sugar control and to consult a healthcare provider regarding potential drug interactions when combining this medication with others. In case of overdose, immediate hospital care should be sought, and rapid medical intervention is necessary if lactic acidosis is suspected.

Serious side effects

• Urticaria
• angioedema
• perineal necrosis
• ketoacidosis
• lactic acidosis
• sepsis
• acute pyelonephritis
• pyelonephritis
• renal failure
• acute kidney injury

Mild side effects

Hypoglycemia, urinary tract infections, genital infections, increased urination, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, constipation, abnormal liver function tests, hepatitis, altered taste, itching, rash, erythema, increased serum lipids, elevated blood creatinine, thirst, elevated blood creatinine / decreased glomerular filtration rate, decreased vitamin B12 and deficiency, decreased fluid volume, weight loss, dizziness, headache, chest discomfort, chest pain, weakness, insomnia, postural hypotension.

This medication should be stored in a tightly closed container to protect it from air and moisture and kept at room temperature between 1 and 30 degrees Celsius. Proper storage can maintain the effectiveness of the medication and prevent deterioration.

Appearance

Pale pink oval-shaped extended-release film-coated tablet

Package unit

30 tablets/bottle