Empagliflozin/Metformin Extended-Release Tablets 25/1000 mg

Adult dose

This medication is taken once daily in the evening with meals. The 10/1000 mg extended-release tablet or the 25/1000 mg extended-release tablet should be taken once daily as 1 tablet. The 5/1000 mg extended-release tablet or the 12.5/1000 mg extended-release tablet should be taken once daily as 2 tablets simultaneously. Increases in the dose of metformin hydrochloride should be made gradually, and this medication should not be crushed, broken, ground, or chewed.

This medication helps regulate blood sugar levels. However, during the use of this medication, there is a risk of a rare complication called lactic acidosis, which warrants caution. Lactic acidosis is a serious condition caused by excessive accumulation of lactic acid in the body, with symptoms including fatigue, muscle pain, difficulty breathing, and abdominal pain. Additionally, this medication may increase the risk of hypoglycemia when taken together with insulin or sulfonylureas, so blood sugar changes should be monitored closely. Patients with impaired kidney function, acute renal failure, dehydration, severe infections, or heart failure should not take this medication. Use of iodine contrast agents requires temporary discontinuation of this medication before and after the tests, and resumption should only occur after normal kidney function is confirmed. Women who are pregnant or may become pregnant are advised against taking this medication, and it should also be avoided during breastfeeding. This medication may increase the risk of genital and urinary tract infections; therefore, if infection symptoms appear, patients should consult their doctor immediately. Elderly patients or those at risk for fluid loss should be aware of dehydration and hypotension and undergo regular kidney function checks. It is advisable to avoid alcohol consumption during treatment and to watch for hypoglycemia after sudden dietary imbalances or intense physical activities. Patients taking this medication should report any unusual symptoms to healthcare professionals immediately and undergo appropriate examinations. The tablets should be swallowed whole without breaking or chewing, and it is normal for the tablet coating to appear in the stool. This medication may interact with other drugs, so if patients are taking any other medications, they must inform their doctor or pharmacist.

Serious side effects

Hives, angioedema, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral or ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme fatigue, sudden severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, significantly reduced urine output

Mild side effects

• Nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation
• altered taste
• itching
• rash
• redness

This medication is sensitive to air and moisture, so it should be stored in a tightly closed container. Additionally, it is recommended to store the medication at room temperature, between 1 to 30 degrees Celsius, avoiding excessively hot or cold conditions.

Appearance

Brownish-red oval extended-release film-coated tablet

Package unit

30 tablets/bottle