Empacombi Extended-Release Tablet 25/1000 mg (Empagliflozin, Metformin)

Adult dose

This medication is administered as one tablet containing 25 mg of empagliflozin and 1000 mg of metformin hydrochloride (extended-release) once daily with meals. To maintain the extended-release properties, it should not be broken, crushed, chewed, or taken apart but swallowed whole. When converting from immediate-release metformin to extended-release formulations, close monitoring of blood glucose control is required, and dosage adjustments should be made accordingly. Dosage adjustments are necessary depending on renal function, and mild renal impairment patients should take care.

This medication is used for the treatment of type 2 diabetes, acting with two components to control blood glucose. While taking this medication, a rare side effect called lactic acidosis may occur, so if symptoms such as shortness of breath, muscle pain, and fatigue arise, immediate consultation with a physician is necessary. Also, when taken with insulin or sulfonylurea medications, there is a risk of hypoglycemia, so blood glucose levels should be carefully monitored. Patients with impaired kidney function or acute renal failure should not use this medication and should undergo regular kidney function tests. Avoid administration in cases of acute infections, dehydration, severe heart failure, and liver dysfunction, and temporary discontinuation is necessary when surgery is planned or contrast agent examinations are to be conducted. This medication may increase the risk of genital and urinary tract infections; hence, rapid treatment should be sought if infection symptoms occur. Vitamin B12 levels may decrease, so monitoring through blood testing is recommended when used long-term. Pregnant or breastfeeding women should not take this medication, particularly if there is a possibility of pregnancy. Elderly patients or those at risk of fluid loss should carefully monitor for dehydration or hypotension symptoms and be well aware of hypoglycemia symptoms. Do not crush, chew, or break the tablets but swallow them whole; it is normal for the tablet coating to be excreted in stool. If an overdose occurs, immediately visit a medical institution for appropriate treatment as there is a risk of lactic acidosis. It is advisable to avoid alcohol consumption during the use of this medication and to inform the physician of any other medications being taken due to potential interactions. No special effects have been reported when operating vehicles or machinery; however, caution is necessary due to possible hypoglycemia or dizziness. To use this medication safely, regular blood tests and strict adherence to the physician's instructions are required.

Serious side effects

Hives, angioedema, perineal necrosis, ketoacidosis, lactic acidosis, urosepsis and pyelonephritis, severe allergic reactions, severe skin adverse reactions, severe edema, acute kidney injury, liver abnormalities (jaundice), myocardial infarction, cerebral infarction, concussion, severe neurological symptoms (headache, seizures, consciousness confusion, vision disturbances, paralysis), heart failure, shock, sepsis, acute myocardial infarction, acute cholecystitis, autoimmune hepatitis, cholelithiasis,

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is best to maintain a storage temperature between 1 to 30 degrees Celsius. This will help maintain the effectiveness and safety of the medication over time.

Appearance

Pink oblong extended-release film-coated tablet

Package unit

30 tablets/bottle