Actosmet Tablets 15/850 mg (Pioglitazone Hydrochloride, Metformin Hydrochloride)

Adult dosage

This medication should generally be administered in divided doses with meals to help reduce gastrointestinal adverse reactions associated with metformin. The initial dose should be based on the patient's current treatment regimen. 1. For patients whose blood sugar is not adequately controlled with monotherapy of metformin or pioglitazone, initiate treatment with this medication starting with one tablet daily based on the current dosage of metformin or pioglitazone.

This medication helps regulate blood sugar levels for patients with type 2 diabetes, and the two components work together to lower blood sugar. When taking this medication, it is essential to confirm that kidney function is normal, as it is safest not to use it if kidney function is impaired. Patients with abnormal liver function or liver disease should consult a physician before taking this medication and should undergo regular liver function tests. Patients with heart disease or heart failure need to be cautious when using this medication, and especially those with severe heart failure should not start taking it. This medication can cause a rare but serious side effect known as lactic acidosis, so if symptoms such as malaise, muscle pain, difficulty breathing, or abdominal pain occur, it is crucial to inform a doctor immediately. Alcohol consumption may increase the risk of side effects from this medication, so excessive drinking should be avoided while taking it. Women who are pregnant or may become pregnant, as well as breastfeeding women, are advised not to take this medication. During treatment with this medication, regular checks of blood sugar, kidney function, liver function, and hematological tests should be conducted to monitor for any abnormalities. There may be interactions with other drugs, so anyone taking other medications should inform their doctor or pharmacist, especially if taking drugs that could affect kidney function. In case of overdose, it is crucial to visit a medical facility for appropriate treatment, and if necessary, dialysis may be performed to remove the medication. This medication has not been proven safe and effective for children, so it is not used in pediatric patients. Elderly patients are likely to have reduced kidney function, so initial and maintenance doses should be determined with caution, and kidney function should be frequently evaluated. Weight gain, edema, and symptoms of heart failure may occur during treatment with this medication, so it is important to consult healthcare providers if these symptoms arise. While taking this medication, it is important to maintain regular meals and exercise and to continually monitor blood sugar control.

Serious side effects

Severe lactic acidosis, hypoglycemia, congestive heart failure, symptoms and signs of heart failure (including rapid weight change, difficulty breathing, edema), acute renal function deterioration, cardiopulmonary disease, sepsis, liver failure, jaundice, severe liver dysfunction, severe edema, severe hypertension, severe allergic reactions, severe skin adverse reactions, sudden and very severe headache, seizures, confusion, visual disturbances, paralysis, dramatically reduced urine output, urinary abnormalities.

Mild side effects

• Upper respiratory infection
• diarrhea
• nausea
• headache
• urinary tract infection
• sinusitis
• dizziness
• lower limb edema
• weight gain
• anemia

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. Ideally, it should be stored at room temperature, between 1 degree and 30 degrees.

Appearance

White to grayish-white, oblong, convex film-coated tablets

Package unit

Blister - 28 tablets/Alu-Alu[(7 X 4ea)], Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle