Isotril Sustained Release Tablet 30 mg (Isosorbide-5-Mononitrate)

Adult dosage

Administer 60㎎ orally once daily in the morning. For angina, the dose may be increased to 120㎎ in the morning as needed. To minimize headache, start with a dose of 30㎎ for 2～4 days and adjust the dose. This drug may be divided into doses, but must not be chewed or crushed; swallow it whole with a beverage.

This medication should not be used in patients with severe heart-related conditions such as acute circulatory failure, severe hypotension, or acute myocardial infarction. It should not be administered to patients who have an allergic reaction to this medication or have severe anemia, head trauma, cerebral hemorrhage, or significant reduced blood volume. Caution is advised as certain heart medications may be dangerous when used concurrently without consultation with a doctor. It should not be administered to patients who are genetically unable to digest lactose due to the lactose contained in this medication. Patients with closed-angle glaucoma, hypothyroidism, hypothermia, malnutrition, or severe liver or kidney problems should be cautious when using this medication. This drug can lower blood pressure, so patients with hypotension or cerebrovascular diseases need to be careful. Initial treatment may cause side effects such as headache, dizziness, or blood pressure lowering, but most symptoms subside over time. Rarely, skin rashes, gastrointestinal symptoms, or liver dysfunction may occur, so if any unusual symptoms arise, one should immediately consult a healthcare professional. This medication is not suitable for immediate relief of angina attacks; in cases of acute attacks, another fast-acting medication should be used. Discontinuing this medication suddenly can worsen symptoms, so dosage should be adjusted gradually as per the physician's instructions. Additionally, caution is necessary when taken with certain antihistamines, vasodilators, or alcohol as this may lead to excessively low blood pressure. Pregnant or nursing women should consult a doctor for careful consideration as this medication may affect the fetus or newborn. Safety has not been established for children, so use is not recommended. In cases of overdose, severe headache, fainting, or blood pressure lowering may occur, and immediate medical attention is required. This medication should be kept out of reach of children, stored in its original container to maintain quality. Lastly, dizziness may occur during the course of taking this medication, so special caution should be exercised while driving or operating machinery.

• headache
• dizziness
• hypotension
• increased heart rate
• low blood pressure
• tachycardia
• syncope
• flushing
• erythema
• redness

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is advisable to maintain a storage temperature between 1 to 30 degrees Celsius at room temperature.

Appearance

Yellow oval-shaped sustained-release film-coated tablet

Package unit

30 tablets/bottle, 500 tablets/bottle