Ezatine Tablets 20 mg (Memantine Hydrochloride)

Adult dose

This medication is administered orally once a day and should be taken at the same time every day. If necessary, it can be administered twice a day. The dosage increase phase involves increasing by 5 mg weekly for the first 3 weeks. First week (Day 1-7): Day 1 5 mg Second week (Day 8-14): Day 1 10 mg Third week (Day 15-21): Day 1 15 mg From the fourth week: Day 1 20 mg The maintenance dose is 20 mg once a day. For patients aged 65 and older

This medication should not be used by patients with hypersensitivity to its ingredients or severe liver or kidney dysfunction. It should be used cautiously in patients with epilepsy or those with a history of seizures, or in patients who are at high risk of developing epilepsy. Additionally, co-administration with NMDA antagonists such as amantadine, ketamine, or dextromethorphan may increase central nervous system side effects, so it is better to avoid such combinations. Patients should be monitored carefully in situations where urinary pH may increase, such as dietary changes or certain urinary tract infections. Caution is advised for patients with myocardial infarction, congestive heart failure, or uncontrolled hypertension, as the safety of this medication has not been fully established in these populations. While taking this medication, side effects such as dizziness, headaches, constipation, drowsiness, and hypertension may occur, and if symptoms are severe, consultation with a healthcare professional is recommended. There may be interactions with other medications, particularly NMDA antagonists, levodopa, dopamine agonists, anticholinergic medications, barbiturates, antipsychotic medications, and skeletal muscle relaxants, so caution is necessary when taken together. Women who are pregnant or may become pregnant should carefully consider the risks to the fetus when using this medication. If breastfeeding, it is advisable to discontinue nursing when administering this medication due to the possibility of transmission through breast milk. For children and adolescents under 18 years of age, its safety and efficacy have not been established, so it is preferable not to use it in this population. In case of overdose, central nervous system symptoms and gastrointestinal symptoms may occur, and since there is no specific antidote, appropriate treatment based on symptoms is needed. This medication may reduce the patient's responsiveness, increasing the risk of accidents while driving or operating machinery, so caution is necessary. Finally, keep this medication out of reach of children, and do not transfer it to other containers as this is safer and better for maintaining quality.

Serious side effects

Seizures, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, paleness), severe skin adverse reactions (severe rash with fever, blisters, peeling skin, pain in mucous membranes of mouth/eyes), respiratory issues (shortness of breath or difficulty breathing, asthma attacks, breathing abnormalities accompanied by cough and fever), liver abnormalities (yellowing of skin or eyes, generalized lethargy), severe acute kidney injury.

Mild side effects

• Dizziness
• headaches
• constipation
• drowsiness
• hypertension
• fungal infections
• drug hypersensitivity reactions
• confusion
• hallucinations
• psychotic reactions

This medication may be sensitive to air or moisture, so it should be stored in a tightly closed container. It is also advisable to avoid extremely hot or cold places and to keep it at room temperature between 1 degree and 30 degrees Celsius.

Appearance

Pink oval film-coated tablets

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle