Diment Duo Tablets 10/20 mg (Donepezil Hydrochloride Hydrate, Memantine Hydrochloride)

Adult dose

For patients requiring combined administration of donepezil hydrochloride 10 mg and memantine hydrochloride 20 mg, it is recommended to switch to this medication for convenience, taking 1 tablet once daily before bedtime at the same time each day. This medication can be taken without regard to meals.

This medication should not be used in certain patients. For example, individuals with allergies to this medication or its components, patients with severe liver or kidney dysfunction, pregnant or breastfeeding women, and people with genetic issues such as lactose intolerance should not take this medication. Additionally, patients with epilepsy or a history of seizures, those taking certain medications, patients with heart disease or hypertension, individuals with a history of peptic ulcers, asthma patients, and those with extrapyramidal disorders such as Parkinson's disease should use this medication with caution. This medication contains donepezil hydrochloride and memantine hydrochloride, each of which may have various side effects. Serious side effects such as heart rhythm disturbances, gastrointestinal bleeding, liver dysfunction, seizures, movement disorders, respiratory difficulties, acute pancreatitis, acute renal failure, and sudden death may occur, so caution is required. Moreover, donepezil hydrochloride may cause hallucinations, insomnia, dizziness, diarrhea, vomiting, decreased appetite, muscle cramps, thrombocytopenia, among various symptoms. Memantine hydrochloride may commonly cause dizziness, headache, constipation, drowsiness, and hypertension. This medication may interact with specific other drugs, so if you are taking other medications, you must consult a doctor or pharmacist. Special caution is needed when combined with heart-related medications, antidepressants, antipsychotics, antibiotics, muscle relaxants, etc. Pregnant or breastfeeding women are advised not to take this medication, and if it must be used, consultation with a specialist is essential. The safety and effectiveness of this medication in children and adolescents under 18 years have not been established, so it should not be used in this population. In cases of overdose, severe vomiting, sweating, bradycardia, seizures, and coma may occur, and immediate medical assistance is required. This medication may affect driving abilities and machine operation, so caution is necessary while taking it. Finally, this medication should be stored out of reach of children and not transferred to other containers.

Serious side effects

Fainting, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcer, perforation of duodenal perforation, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizure, epilepsy, seizures, cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (movement dysfunction, ataxia, motor disorders, dystonia, tremor, involuntary movements, gait disturbances, abnormal posture, speech disorders), neuroleptic malignant syndrome (stupor, extreme lethargy)

Mild side effects

• Loss of appetite
• hallucinations
• agitation
• aggressive behavior
• anxiety
• insomnia
• drowsiness
• increased libido
• talkativeness
• mania

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 1°C and 30°C room temperature. Storing it this way will safely preserve its efficacy.

Appearance

Pale yellow oval film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle