Improvement of cognitive function in Alzheimer's disease
Who takes it
Adults
Adult dose
10 mg of Donepezil Hydrochloride and 20 mg of Memantine Hydrochloride should be administered once daily with one tablet before bedtime at the same time each day. This medication can be taken without regard to food intake.
Improvement of cognitive function in Alzheimer's disease
Moderate Alzheimer's disease
severe Alzheimer's disease
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This medication is used as an alternative treatment for combination therapy using donepezil and memantine to treat moderate to severe Alzheimer's disease. It helps to improve cognitive decline due to Alzheimer's disease and enhance daily living abilities. Therefore, this medicine is used to assist patients in maintaining better functionality in their daily life.
How to take
Adult dose
10 mg of Donepezil Hydrochloride and 20 mg of Memantine Hydrochloride should be administered once daily with one tablet before bedtime at the same time each day. This medication can be taken without regard to food intake.
Precautions
This drug should not be used in certain patients. For example, patients who are allergic to this medication or its components, patients with severe liver or kidney dysfunction, women who are pregnant or breastfeeding, and patients with genetic issues such as lactose intolerance should not be administered this drug.
Additionally, patients with epilepsy or a history of seizures, patients on certain concomitant medications, patients with uncontrolled heart disease or hypertension, and patients with asthma or lung disease should use this drug with caution.
This drug may have various side effects, notably gastrointestinal issues (nausea, vomiting, diarrhea), neurological problems (dizziness, hallucinations, insomnia), cardiovascular issues (bradycardia, palpitations), and musculoskeletal problems (muscle pain, cramps) have been reported.
Particularly, if heart-related side effects or severe allergic reactions occur, medication should be stopped immediately, and consultation with healthcare professionals is necessary.
During pregnancy or breastfeeding, as the safety of this drug has not been established, its use should be avoided or discussed with experts.
This drug is not used in children or adolescents under 18 years of age as safety and efficacy have not been confirmed.
In cases of overdose, symptoms such as nausea, vomiting, confusion, drowsiness, and convulsions may occur, so immediate medical attention for appropriate treatment is essential.
This drug may affect driving or operating machinery, so caution is necessary while under treatment.
Finally, this drug should be kept out of reach of children, and it is safe not to transfer it to another container.
Side effects and when to seek care immediately
Serious side effects
Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory distress with cough + fever, yellowing of skin or eyes (jaundice), extreme fatigue, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, vision disturbances, paralysis, urination issues.
Mild side effects
Cold
loss of appetite
hallucinations
agitation
aggressive behavior
anxiety
insomnia
drowsiness
increased libido
talkativeness
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mania
nightmares
nervousness
nonsensical speech
delusions
depression
confusion
apathy
hyperactivity
dizziness
tremors
diarrhea
nausea
vomiting
abdominal distress
constipation
salivation
difficulty swallowing
fecal incontinence
headache
fatigue
pain
toothache
facial flushing
malaise
lethargy
edema
fever
decreased body temperature
decreased hematocrit.
Not everyone experiences these, and they can vary from person to person.
Storage
This medication should be stored in a tightly sealed container to avoid exposure to air or moisture, and it should be stored at room temperature, between 1 degree and 30 degrees Celsius.
By storing it this way, the effectiveness of the medication can be maintained, and degradation can be prevented.
Appearance and packaging
Appearance
Oval, film-coated tablets of dark yellow color
Package unit
100 tablets/bottle, 30 tablets/bottle
Same-ingredient medicines
Even with the same ingredient, strength, dosage form and how it is taken can differ.
Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.
Questions about this medicine
No questions yet.
For anything that needs medical judgment, consult a doctor or pharmacist.
This drug information is based on data provided by the Korea Ministry of Food and Drug Safety. Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.