Alzcomp Tablet 10/20 Milligrams (Donepezil Hydrochloride Hydrate, Memantine Hydrochloride)

Adult dose

For patients who require the combined administration of donepezil hydrochloride 10mg and memantine hydrochloride 20mg, take one tablet orally once daily at the same time each day before bedtime. It can be taken regardless of food intake.

This medication should not be used in certain patients. Specifically, individuals allergic to this drug or its components, those with severe liver or kidney impairment, women who are pregnant or breastfeeding, and those with genetic conditions such as lactose intolerance should not be administered this medication. Additionally, patients with epilepsy or a history of seizures, those taking certain neurological drugs, individuals with heart disease or hypertension, those with a history of peptic ulcer, those with asthma or lung disease, and those with extrapyramidal disorders such as Parkinson's disease should exercise caution when using this medication. This medication is composed of donepezil hydrochloride and memantine hydrochloride, and various side effects reported for each component may occur. Serious side effects such as cardiac issues, gastrointestinal bleeding, hepatic dysfunction, epileptic seizures, movement disorders, severe muscle problems, respiratory distress, pancreatitis, renal failure, and sudden death may rarely occur with donepezil hydrochloride; symptoms should prompt immediate consultation with a healthcare professional. Additionally, various mild side effects such as dizziness, nausea, vomiting, diarrhea, insomnia, depression, hallucinations, anxiety, muscle pain, etc., have been reported. Memantine hydrochloride may commonly cause side effects such as dizziness, headache, constipation, drowsiness, and hypertension. This medication requires special caution in patients with heart disease or electrolyte abnormalities, those with a history of gastric ulcers, and those with respiratory illnesses, who may need electrocardiograms, blood pressure monitoring, and hepatic function tests during treatment. It is principle that women who are pregnant or breastfeeding avoid this medication, and if necessary, it should be used after consulting with a specialist. This medication is not used in children and adolescents under 18 years old, as safety and efficacy have not been established. In case of overdose, severe symptoms such as nausea, vomiting, bradycardia, seizures, and coma may occur, requiring immediate treatment at a hospital, possibly including an antidote or special therapy. Finally, this medication may affect driving or machinery operation abilities, so caution is advised while taking it. Lastly, the medication should be stored out of reach of children and not transferred to another container.

Serious side effects

Fainting, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcer, perforating duodenal perforation, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizure, convulsions, cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (motor dysfunction, ataxia, dystonia, etc.), neuroleptic malignant syndrome, rhabdomyolysis, dyspnea, acute pancreatitis, acute renal failure, sudden death, severe allergic reactions (hives, severe swelling)

Mild side effects

• Loss of appetite
• insomnia
• drowsiness
• dizziness
• headache
• fatigue
• nausea
• vomiting
• diarrhea
• abdominal pain

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. Additionally, it is important to avoid extremely hot or cold places, keeping it stored at room temperature between 1°C and 30°C.

Appearance

Yellowish oval film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle