Sergol Tablets 10 mg (Nisergoline)

Adult dose

* 5 mg, 10 mg Adults: Administer 5 ∼ 10 mg of nicergoline orally 3 times daily before meals. Adjust the dose appropriately according to symptoms. * 30 mg Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, the dose may be increased to 60 mg. The dose may be reduced after symptoms improve. For patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL), administer a reduced dose.

This medication should not be used in certain patients. For example, individuals allergic to this medication or ergot alkaloids, those with acute myocardial infarction or acute bleeding, those taking sympathomimetic drugs, those with very slow heart rates, those who have not stopped bleeding after intracranial hemorrhage, and those with orthostatic dysregulation should not take this medication. Additionally, patients with mild bradycardia or impaired renal function should use this medication cautiously. Side effects may include gastrointestinal symptoms like decreased appetite, diarrhea, constipation, nausea, and vomiting, which can occasionally occur, and liver function test values may rise. Cardiovascular symptoms such as dizziness, orthostatic hypotension, hypertension, and blood pressure drops can also occur rarely. Mentally, drowsiness, fatigue, headache, and insomnia may appear, and skin reactions such as rashes or itching can occur infrequently. This medication acts to lower blood pressure, so it should be taken with caution alongside other antihypertensives to prevent excessive blood pressure drops; regular blood pressure monitoring is required. It may also affect uric acid metabolism, so patients with a history of gout should be cautious. Care should be taken when driving or operating machinery after taking this medication. It is metabolized in the liver by a specific enzyme (CYP450 2D6), and it may interact with other drugs that use this enzyme. Women who are pregnant or may become pregnant should use this medication cautiously under the judgment of their doctor as its use is not considered safe, and breastfeeding mothers should avoid taking it or consider stopping breastfeeding. Elderly patients may have decreased bodily functions, necessitating dose adjustments. Safety has not been established for pediatric patients, so use is not recommended. In case of overdose, blood pressure may temporarily drop, so blood pressure changes should be monitored, and appropriate measures should be taken if necessary. Finally, this medication should be kept out of reach of children and stored sealed in its original container to maintain its quality.

Loss of appetite, diarrhea, constipation, nausea, vomiting, incidental upper abdominal pain or cramps, thirst, elevated ALT, elevated AST, dizziness, orthostatic dysregulation, hypertension, elevated blood uric acid, hypotension, drowsiness, fatigue, headache, tinnitus, tiredness, insomnia, rash, urticaria, itching, flushing, heat sensation, nightmares, mood disturbances, dyspepsia

This medication should be stored in a light-protected, tightly sealed container and kept at room temperature between 1°C and 30°C. This helps maintain the medication's effectiveness and prevent deterioration.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle