Sitagliptin, Dapagliflozin, Metformin Prolonged-Release Tablets 10/100/1000 mg

Adult dose

Patients taking this medication in 10/100/1000 mg prolonged-release tablet form should take one tablet once daily. Patients taking this medication in 5/50/500 mg, 5/50/750 mg, and 5/50/1000 mg prolonged-release tablets should take two tablets once daily. This medication should be taken once daily in the evening with meals to minimize gastrointestinal side effects associated with metformin hydrochloride, and if dose adjustment is needed,

This medication contains three components used in diabetes treatment: dapagliflozin, sitagliptin, and metformin. First, the sitagliptin component can rarely cause serious allergic reactions, so if symptoms such as skin rash, angioedema, or difficulty breathing occur within three months of administration, treatment should be stopped immediately, and a doctor should be consulted. Additionally, acute pancreatitis may occur, so if symptoms such as abdominal pain, nausea, or vomiting arise, seek medical attention promptly. The metformin component may rarely cause a serious metabolic disorder known as lactic acidosis, which should not be used in patients with diminished kidney function or poor liver function. Symptoms of lactic acidosis include fatigue, muscle pain, difficulty breathing, and abdominal pain; if such symptoms occur, immediate medical attention should be sought. This medication should not be used in patients with moderate to severe renal impairment, dehydration, severe infections, cardiovascular collapse, acute myocardial infarction, sepsis, or other acute conditions that can affect renal function. Also, this medication should be discontinued for a specified period before and after tests involving iodinated contrast agents and should only be resumed after kidney function is confirmed to be normal. This medication carries a risk of decreased fluid volume and hypotension; therefore, patients, especially the elderly or those on diuretics, should be thoroughly assessed for fluid status and renal function before taking it, and blood pressure symptoms and renal function should be regularly monitored during treatment. Also, while taking this medication, genital infections or urinary tract infections may occur, and symptomatic treatment should be sought. Rarely, a serious infection known as perineal necrosis may develop, so if there is pain, swelling, or redness around the genital area, inform medical personnel immediately. This medication can cause hypoglycemia, so especially when used in combination with other antihyperglycemic agents, patients should be alert to symptoms of hypoglycemia. Pregnant women, patients with severe liver dysfunction, acute heart failure, type 1 diabetes, or a history of diabetic ketoacidosis should not take this medication. Finally, it is recommended to regularly monitor kidney and liver function during treatment and to periodically check vitamin B12 levels. Patients taking this medication should consult a doctor or pharmacist immediately if any of the aforementioned symptoms or adverse reactions occur.

Serious side effects

• Hives
• angioedema
• chest tightness
• difficulty breathing
• clamminess
• pallor
• anaphylaxis
• severe hypersensitivity reactions
• Stevens-Johnson syndrome
• rash

Mild side effects

• Hypoglycemia
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• headache
• dizziness
• constipation
• dry mouth

This medication should be stored in a tightly closed container to prevent exposure to air and moisture, and it is recommended to keep it at room temperature between 1 to 30 degrees Celsius. Storing it this way helps to maintain the medication's efficacy and prevent degradation.

Appearance

Pink oval-shaped prolonged-release film-coated tablets

Package unit

30 tablets per bottle