Nisem Tablets 10 mg (Nisergoline)

Adult dose

* 5 mg, 10 mg Adults: Administer 5–10 mg of nicergoline orally 3 times daily before meals. Adjust the dose as appropriate according to symptoms. * 30 mg Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, the dose may be increased to 60 mg. The dose may be reduced after symptoms improve. In patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL), administer a reduced dose.

This drug should not be used in certain patients. For example, individuals allergic to this drug or ergot alkaloids, as well as those with acute myocardial infarction or acute hemorrhage, should not take it. Moreover, patients who have a very slow heart rate, those who have not completed hemostasis after intracranial hemorrhage, and those with orthostatic hypotension should also avoid this drug. Mild bradycardia patients or those with poor kidney function should use this medication cautiously. Rarely, gastrointestinal symptoms such as indigestion, diarrhea, constipation, vomiting, and abdominal pain may occur upon taking this drug. Liver function test results may become elevated, and dizziness, blood pressure changes, drowsiness, headaches, and fatigue may also occur infrequently. Allergic reactions such as skin rashes or itching may also be observed. This drug lowers blood pressure, so when taken with other antihypertensive medications, blood pressure should be monitored frequently. It may affect uric acid levels, so caution is advised for individuals with a history of gout. After taking this medication, careful attention is required while driving or operating machinery. This drug is metabolized by specific enzymes in the liver, so interactions may occur when taken with other drugs related to these enzymes. Women who are pregnant or may become pregnant should carefully consider the risks and benefits of taking this medication. Animal studies have reported potential harm to the fetus, and since this drug can be excreted in breast milk, it is advisable to avoid taking it or to discontinue breastfeeding if possible. The elderly may have decreased physical functions, so precautions such as reducing the dosage should be taken when taking this medication. The safety of this drug in children has not been sufficiently established, so its use is not recommended. In cases of overdose, temporary drops in blood pressure may occur, necessitating close monitoring of blood pressure and appropriate measures. Finally, this medication should be kept out of reach of children, and transferring it to another container may compromise its quality or lead to misuse, so it must be stored in its original container with the lid tightly closed.

• Loss of appetite
• diarrhea
• constipation
• nausea
• vomiting
• intermittent upper abdominal pain
• cramps
• thirst
• ALT elevation
• AST elevation

This drug should be stored in a tightly sealed container that is light-resistant and at room temperature between 1°C and 30°C. Storing it in this manner helps maintain the drug's effectiveness and prevents degradation.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle