Dementherin 30 mg (Nisergoline)

Adult dose

Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, the dose may be increased to 60 mg. The dose may be reduced after symptoms improve. Reduce the dose in patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL).

This medication should not be used in patients who have an allergic reaction to this medication or ergot alkaloids. It should also not be administered to patients with acute myocardial infarction or acute bleeding. Patients taking sympathomimetic medications or those with very slow heart rates should not use this medication. It is also contraindicated in patients who have not stopped bleeding after a cerebral hemorrhage and those with orthostatic hypotension. Patients with mild bradycardia or impaired kidney function should use this medication with caution. Gastrointestinal symptoms such as loss of appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, and dry mouth may occur rarely. Liver function abnormalities may lead to increased liver enzyme levels. Cardiovascular symptoms such as dizziness, orthostatic hypotension, blood pressure changes, and increased blood uric acid levels may also be reported rarely. Psychologically, symptoms such as drowsiness, fatigue, headache, insomnia, and tinnitus may occur. Allergic reactions can manifest as skin rash, urticaria, itching, facial flushing, and warmth. Taking this medication with other antihypertensive agents may lead to excessively low blood pressure, so blood pressure should be monitored frequently. It may affect uric acid metabolism, so gout patients should be cautious. Caution is necessary when driving or operating machinery after taking this medication. This medication is metabolized in the liver, so it may interact with other drugs; consultation with a physician or pharmacist is necessary. Pregnant or breastfeeding women should consult with healthcare professionals before taking this medication, especially during early pregnancy when it may pose risks. Elderly patients may require dose adjustments due to weakened physical functions. Safety in children has not been established, so it is advised not to use it. In case of overdose, blood pressure may temporarily drop, and blood pressure should be monitored if necessary. This medication should be stored out of reach of children and kept in its original container for safety.

• Loss of appetite
• diarrhea
• constipation
• nausea
• vomiting
• localized upper abdominal pain or cramps
• dry mouth
• elevated ALT
• elevated AST
• dizziness

This medication should be stored in a tightly closed container to protect it from air and moisture. Additionally, it is best to store the medication at room temperature between 1 to 30 degrees Celsius.

Appearance

Light yellow round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle