Niseon Tablets 10 mg (Nisergoline)

Adult dose

* 5 mg, 10 mg Adults: Administer 5 ∼ 10 mg of nicergoline orally 3 times daily before meals. Adjust the dose as appropriate according to symptoms. * 30 mg Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, the dose may be increased to 60 mg. The dose may be reduced after symptoms improve. For patients with renal impairment (serum creatinine >175 µmol/L) (2 mg/dL), administer a reduced dose.

This medication should not be used in certain patients. Individuals allergic to this drug or to ergot alkaloids should not take it. Patients with acute myocardial infarction or acute bleeding should also avoid this medication. Those taking sympathomimetic drugs, patients with significantly low heart rates (under 50 beats per minute), patients who have not completed hemostasis after intracranial hemorrhage, and individuals with orthostatic dysregulation should refrain from using this drug. Caution is required for patients with mild bradycardia or renal function issues when taking this medication. Rarely, symptoms such as dyspepsia, diarrhea, constipation, nausea, vomiting, abdominal pain, dry mouth may occur. Liver function tests may show elevated levels, so liver health should be monitored. Cardiovascular symptoms like dizziness, blood pressure changes, and orthostatic hypotension can also occur rarely. Neurological symptoms such as drowsiness, headache, fatigue, and insomnia have also been reported. Allergic reactions may manifest as rashes, hives, itching, facial flushing, and warmth, necessitating immediate notification of any unusual symptoms. When taken with other antihypertensive medications, blood pressure may decrease excessively, so blood pressure should be routinely monitored. It may affect uric acid levels, so patients with a history of gout should use caution. Be careful when driving or operating machinery after taking this medication. This drug is metabolized in the liver by a specific enzyme (CYP450 2D6), and interactions may occur with other medications using this enzyme. Women who are pregnant or may become pregnant should carefully assess the risks and benefits of using this drug, and breastfeeding women should avoid taking it if possible or stop breastfeeding. The elderly may need to adjust the dosage due to decreased bodily functions. Safety for pediatric use has not yet been established, so it is advisable to avoid its use. In cases of overdose, blood pressure may temporarily decrease, so changes in blood pressure should be closely monitored, and appropriate measures should be taken when necessary. This medication should be stored out of the reach of children and kept sealed in its original container.

• Loss of appetite
• diarrhea
• constipation
• nausea
• vomiting
• acute upper abdominal pain or cramping
• dry mouth
• ALT elevation
• AST elevation
• dizziness

This drug should be stored in a tightly closed container to prevent air and moisture from entering, and it is recommended to keep it at room temperature between 1 and 30 degrees. Proper storage will help maintain the drug's efficacy over time.

Appearance

White, round, film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle