Avesmet Tablet 50/1000 mg (Vildagliptin, Metformin Hydrochloride)

Adult dose

The dosage of this medication should be individualized within the range of 100 mg of Vildagliptin and 2000 mg of Metformin. A dosage of Vildagliptin greater than 100 mg per day is not recommended. Administering with food or immediately after meals may reduce gastrointestinal adverse effects associated with Metformin. 1. For patients without prior experience of diabetes medication treatment and for whom blood sugar control is difficult with monotherapy: Starting dosage of 50 mg

This medication contains Metformin and Vildagliptin and is used for the treatment of diabetes. The most important caution when taking this medication is the risk of a serious side effect known as lactic acidosis. Lactic acidosis is a dangerous condition caused by the excessive buildup of lactic acid in the body, and immediate treatment is necessary if symptoms appear. Patients with moderate to severe renal impairment should not take this medication. Impaired kidney function can lead to drug accumulation in the body and increase the risk of side effects. Patients with heart failure, cardiovascular issues, acute infections, severe trauma, or liver dysfunction should also avoid this medication. In particular, patients scheduled for surgery should stop this medication 48 hours prior to the surgery and restart only after renal function has been confirmed as normal post-surgery. Pregnant or breastfeeding women should not take this medication, nor should patients with genetic conditions such as lactose intolerance. During treatment with this medication, patients should be cautious if they have irregular meal patterns, engage in intense exercise, or take other medications, as the risk of hypoglycemia or lactic acidosis may increase. Common side effects of this medication include dizziness, headache, nausea, and hypoglycemia; rare side effects such as liver dysfunction and skin rash have also been reported. If symptoms of acute pancreatitis occur, stop taking the medication immediately and seek medical attention. Alcohol consumption may increase the risk of lactic acidosis when taken with this medication, so it is advisable to avoid drinking. Regular monitoring of kidney and liver function is required while taking this medication, and periodic blood tests are recommended as vitamin B12 deficiency may occur. In case of overdose, immediate treatment is necessary, and blood dialysis may be helpful. Special caution is needed for children, adolescents, and the elderly, and dosage adjustment is necessary for the elderly due to decreased kidney function. Finally, be cautious during activities such as driving or operating machinery if symptoms like dizziness appear while taking this medication.

Serious side effects

• Hives
• angioedema
• hepatitis
• jaundice
• severe joint pain with disability
• blistering and exfoliative skin lesions
• pancreatitis
• lactic acidosis
• acute pancreatitis
• severe lactic acidosis

Mild side effects

• Headache
• dizziness
• tremor
• fatigue
• nausea
• gastroesophageal reflux
• diarrhea
• bloating
• chills
• decreased blood sugar

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is best to maintain a storage temperature between 1 and 30 degrees Celsius. Proper storage will help preserve the medication's effectiveness and prevent degradation.

Appearance

Dark yellow oval film-coated tablet

Package unit

30 tablets/bottle, 60 tablets/box [10 tablets/PTP X 6]