Trip Em Duo Tablet 2.5/850 mg (Linagliptin, Metformin)

Adult dose

The dosage of this drug is determined considering the current treatment regimen, efficacy, and tolerability of each patient, not exceeding the maximum recommended dosage of Linagliptin 2.5 mg (Linagliptin besilate 3.34 mg) and Metformin 1000 mg, administered twice daily. This drug is taken twice daily with meals. 1. If currently not treated with Metformin: Initial dosage of this drug is 2.5/500 mg.

This drug is used for the treatment of diabetes. However, it should not be administered to patients with poor kidney function or severe liver dysfunction. Rare but serious side effects such as lactic acidosis may occur, so kidney and liver function should be checked periodically. Also, patients with unstable heart function or cardiovascular diseases such as acute myocardial infarction should avoid using this drug. Pregnant or breastfeeding women should not take this drug. This drug has a risk of hypoglycemia, so when used in conjunction with insulin or sulfonylurea class medications, blood sugar conditions should be carefully monitored. If symptoms such as abdominal pain, severe muscle pain, difficulty breathing, or weakness occur during use, consult a doctor immediately. Rare side effects such as acute pancreatitis or bullous pemphigoid with skin blisters may occur, so if such symptoms arise, discontinue the medication and consult a specialist. This drug may lower vitamin B12 levels, so regular testing of vitamin B12 levels is necessary during long-term use. Furthermore, caution should be taken when taken with other medications that can affect kidney function, and dosage adjustment may be required as needed. In special situations such as surgery or radiation examinations, the use of this drug should be temporarily suspended, and resumption should occur only after kidney function stabilizes. Elderly patients are at higher risk of reduced kidney function, so kidney function should be monitored frequently, and appropriate dosage adjustments should be made when using this drug. The safety and efficacy of this drug in children have not been fully established, thus it is not recommended for children under 10 years old. Lastly, this drug should be stored out of reach of children and kept away from moisture.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, liver dysfunction (abnormal liver function tests, hepatitis), angina, acute myocardial infarction, unstable angina, congestive heart failure, cardiac arrest, pneumonia, difficulty breathing, asthma, acute kidney injury, end-stage renal disease, acute cholangitis, acute cholecystitis, cholangitis, erythema, severe allergic reactions, severe skin adverse reactions, respiratory problems, liver impairment (jaundice), serious neurological.

Mild side effects

• Nasopharyngitis
• hypersensitivity
• angioedema
• hypoglycemia
• taste disorder
• cough
• decreased appetite
• diarrhea
• constipation
• nausea

This drug may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is advisable to maintain a storage temperature between 1 to 30 degrees Celsius (room temperature). This will help maintain the effectiveness and safety of the drug for an extended period.

Appearance

Orange, biconvex, oval, film-coated tablet

Package unit

30 tablets/bottle, 60 tablets/bottle