Tranta Duo Tablet 2.5/850 mg

Adult dose

This medication is administered two times a day with meals. The dosage should not exceed linagliptin 2.5 mg and metformin 1000 mg twice daily, taking into account each patient’s current therapeutic regimen, efficacy, and tolerability. 1. If not being treated with metformin: The initial dose is this medication 2.5/500 mg taken twice daily, one tablet per dose, escalating to 2.5/1000 mg twice daily, one tablet per dose.

This medication may rarely cause a serious side effect known as lactic acidosis, so caution is required. Do not administer this medication to patients who have allergies to any active or inactive ingredients, or to patients with type 1 diabetes, lactic acidosis, or diabetic ketoacidosis. It should not be used in patients with severely impaired kidney function, severe renal failure, acute myocardial infarction, shock, severe infections, or any condition that may affect kidney function. Patients with impaired liver function, severe gastrointestinal disorders, acute alcohol intoxication, and alcohol use disorder, as well as those in a state of nutritional deficiency, are advised not to use this medication. Pregnant or breastfeeding women should not use this medication, and those planning pregnancy should consult their physician. When taking this medication with sulfonylureas or insulin, the risk of hypoglycemia increases, so blood glucose should be carefully monitored. Regular kidney function testing is necessary to adjust the dosage appropriately, particularly in the elderly who are more prone to kidney function decline. If iodine contrast media is to be used during radiological examinations, this medication should be temporarily discontinued before and after the examination, and may be resumed only after kidney function stabilizes. In cases of acute surgery, this medication should be discontinued 48 hours prior, and resumed once kidney function has recovered post-surgery. If symptoms such as pancreatitis or bullous pemphigoid occur during treatment, consult a physician immediately and discontinue the medication if necessary. Long-term use may lead to vitamin B12 deficiency, so it is recommended to routinely check vitamin B12 levels. The risk of lactic acidosis may increase when this medication is taken with alcohol, thus alcohol consumption should be avoided. This medication may interact with other drugs, so it is advised to discuss any medications, especially those affecting kidney function, with healthcare professionals. Use in children under 10 years or adolescents is not recommended, and safety and efficacy in pediatric patients over 10 years have not been sufficiently established. There is insufficient research on the effects on driving or operating machinery, so caution is advised. In the case of overdose, gastrointestinal disturbances and lactic acidosis may occur, and immediate medical treatment should be sought if symptoms appear.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, abnormal liver function tests, hepatitis, rash, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or breathing difficulties, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), profound lethargy, sudden and severe

Mild side effects

• Nasopharyngitis
• hypersensitiveness
• urticaria
• decreased and deficient vitamin B12
• hypoglycemia
• taste disturbance
• cough
• reduced appetite
• diarrhea
• constipation

This medication should be stored in a tightly closed container to keep air and moisture out. It is recommended to maintain storage temperatures between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness over time.

Appearance

Bright orange, biconvex, oval film-coated tablets

Package unit

30 tablets/box [(6 tablets/PTP x 5 packs)]