Polminlina Controlled-Release Tablets 5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication should be taken once daily with the evening meal. For the 5/1000 mg controlled-release tablet, take 1 tablet once daily. For the 2.5/1000 mg controlled-release tablet, take 2 tablets simultaneously once daily. The maximum recommended daily dose should not exceed 5 mg of linagliptin and 2000 mg of metformin hydrochloride. The increase in the dose of metformin hydrochloride should be gradual, and do not split or crush the tablets.

This medication contains two components, metformin and linagliptin, and is primarily used for the treatment of type 2 diabetes. This medication can rarely cause a serious condition called lactic acidosis, so patients with poor kidney function or acute illness should not use it. Patients who are allergic to any ingredients or components of this medication, as well as patients with type 1 diabetes or severe liver dysfunction, should also avoid taking it. This medication may cause hypoglycemia; therefore, caution is especially needed when used in conjunction with other hypoglycemic agents like insulin or sulfonylureas. Elderly patients with weakened kidney function or situations where acute kidney injury is a concern may require dose adjustment and kidney function monitoring. Adverse effects such as acute pancreatitis or bullous skin diseases may occur, so if severe abdominal pain or skin abnormalities arise during treatment, notify a doctor immediately. This medication may lower vitamin B12 levels, so it is important to regularly check for vitamin B12 deficiency if taken for an extended period. When taking this medication, do not crush or chew the tablets; swallow them whole, and it is normal for the tablet coating to appear in the stool. This medication may interact with certain other drugs, so patients taking other medications should consult a doctor or pharmacist. Pregnant or breastfeeding women are advised not to use this medication, and those planning to become pregnant should consult a doctor. Safety for pediatric patients has not been established, and elderly patients should adjust the dose according to kidney function and routinely monitor kidney function. In cases of overdose, serious side effects like lactic acidosis may occur, so it is important to adhere strictly to the recommended dosage and seek medical attention immediately if any abnormal symptoms appear. Store this medication out of reach of children, avoiding moisture and not transferring it to other containers.

Serious side effects

Hives, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, difficulty breathing, liver function abnormalities (liver dysfunction, hepatitis, jaundice), severe allergic reactions, acute renal failure, acute myocardial infarction, angina, heart failure, unstable angina, cardiac arrest, acute pancreatitis, angioedema, severe and debilitating joint pain, angioedema, increased blood pressure, acute cholangitis, acute cholecystitis, cholangitis, cholelithiasis, acute kidney injury, acute bile duct

Mild side effects

Disturbance of taste, cough, loss of appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcers, liver function abnormalities, hepatitis, itching, erythema, rash, muscle pain, joint pain, increased lipase, increased amylase, nasopharyngitis, hypersensitivity reactions, angioedema, abnormal vitamin B12 absorption test results, hypoglycemia, decreased hemoglobin, dizziness, anxiety, affective disorders, insomnia, depression, chest pain, fever, facial swelling, fatigue, increased blood pressure,

This medication should be stored in a tightly sealed container to protect it from exposure to air or moisture. It is important to maintain a storage temperature between 1°C and 30°C.

Appearance

White oval controlled-release film-coated tablets

Package unit

30 tablets / bottle