Trajuno Sustained-release Tablets 5/1000 mg (Linagliptin, Metformin)

Adult dose

This medication may be administered to patients taking Linagliptin 5 mg and Metformin Hydrochloride (sustained release) 1000 mg, one tablet daily with food. To reduce gastrointestinal side effects associated with Metformin, it is recommended to take this medication ideally during dinner. To maintain its sustained-release properties, this medication should not be split, crushed, ground, or chewed, and it may be excreted in an incomplete dissolved state in the stool.

This medication is an anti-diabetic agent containing two main components: Linagliptin and Metformin. Firstly, Metformin can rarely cause a serious metabolic disorder called lactic acidosis, which can be life-threatening if not treated immediately. Secondly, this medication should not be used in certain patients, such as those allergic to this medication or in patients with Type 1 diabetes, severely impaired kidney function, acute infections or severe dehydration, and those with liver dysfunction. Thirdly, there is a risk of hypoglycemia, so caution is warranted when used with other hypoglycemic agents such as insulin or sulfonylureas, and dosage adjustments may be necessary as needed. Fourthly, kidney function significantly impacts the safety and efficacy of this medication, thus regular kidney function tests should be conducted before and during treatment, and this medication should not be used in cases of impaired kidney function. Fifthly, this medication should be temporarily discontinued around acute surgeries or examinations using radioactive iodine contrast agents, and can only be resumed after kidney function returns to normal. Sixthly, it is advisable not to use this medication during pregnancy, and it is also safe to avoid use while breastfeeding. Seventhly, long-term use may lead to Vitamin B12 deficiency, so Vitamin B12 levels should be monitored regularly as needed. Eighthly, taking this medication with alcohol may increase the risk of lactic acidosis, hence alcohol consumption should be avoided. Ninthly, if abdominal pain, persistent vomiting, breathing difficulties, muscle weakness, severe skin rashes or blisters occur, immediate consultation with a physician is required. Finally, this medication must be swallowed whole without chewing, breaking, crushing, or chewing the tablet, and it is normal for the shell of the tablet to be excreted in the stool.

Serious side effects

Hives, angioedema, lactic acidosis, severe hypoglycemia, acute pancreatitis, pseudomembranous colitis, unstable angina, acute myocardial infarction, unstable angina, cardiac arrest, liver function abnormalities (liver function test abnormalities, hepatitis), fever, chest tightness, difficulty in breathing, asthma, respiratory distress, increased blood pressure, chest pain, fever, facial swelling, severe myasthenia, confusion, severe edema, hematuria, acute renal injury, end-stage renal disease, acute cholangitis, acute cholecystitis

Mild side effects

• Pharyngitis
• taste disorder
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcers

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, and it is safe to store it at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain its effectiveness and prevent deterioration.

Appearance

Pink oval film-coated sustained-release tablet

Package unit

30 tablets/bottle