Janus Duo Tablets 50/500 mg (Sitagliptin Phosphate Hydrate, Metformin Hydrochloride)

Adult dose

This medicine is generally taken orally twice a day with food, and the dosage is gradually increased to reduce gastrointestinal side effects caused by metformin. 1. For patients who are not currently being treated with metformin: The initial dosage is 50/500 mg taken twice daily, with one tablet per dose, and can be increased to 50/1000 mg taken twice daily, one tablet at a time. 2. For patients currently treated with metformin:

This medicine consists of two components, each used for diabetes treatment. The first component is a drug that helps control blood sugar, and the second component acts to lower blood sugar. When taking this medicine, severe allergic reactions may occur, so if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck appear, discontinue use immediately and notify a healthcare provider. Additionally, pancreatitis may develop, so if symptoms like abdominal pain, vomiting, or loss of appetite occur, consult a physician immediately. This medicine should not be used in patients with poor kidney function, acute heart failure or heart attack, acute infections or dehydration, and in women who are pregnant or breastfeeding. Particularly, if a diagnostic test involving iodine contrast media is planned, this medicine should be discontinued before and after the examination, resuming only after confirming normal kidney function. Rare but serious side effects such as lactic acidosis may occur during use. If abnormal symptoms such as muscle pain, difficulty breathing, fatigue, or abdominal pain appear, inform healthcare personnel immediately. Moreover, alcohol consumption can increase the risk of lactic acidosis, so avoiding alcohol is advisable. This medicine can cause hypoglycemia, hence caution is needed when skipping meals, irregular eating, or excessive exercise. The risk of hypoglycemia may increase when taken with other blood sugar-lowering agents, so blood sugar levels should be monitored frequently. During use, regular monitoring of kidney function and blood vitamin B12 levels is necessary to ensure no abnormalities, and caution is also required for patients with impaired liver function. In case of surgery, discontinue this medicine 48 hours prior to the operation, and it should be resumed only after confirming the recovery of normal kidney function post-surgery. If severe rash or blisters appear on the skin during treatment, alert a doctor immediately and seek treatment. The safety and effectiveness of this medicine have not been established in children under 18 years of age, and the elderly may require dosage adjustment and regular monitoring due to the possibility of reduced kidney function.

Serious side effects

Hives, severe hypersensitivity reactions (including anaphylaxis, angioedema, rash), exfoliative skin disease (Stevens-Johnson syndrome), acute pancreatitis (including hemorrhagic or necrotizing), severe lactic acidosis, acute renal failure, dyspnea, respiratory issues, severe edema, increased blood pressure, severe headache, seizures, confusion, visual disturbances, paralysis, severe edema, acute or chronic liver dysfunction (including jaundice), severe consequences and disability

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• constipation
• nasopharyngitis
• thrombocytopenia
• muscle pain

This medicine should be stored in a tightly sealed container that is well-ventilated, and it is best kept at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the effectiveness of the medicine for a long time.

Appearance

Bright pink oval film-coated tablet

Package unit

30 tablets per bottle, 120 tablets per bottle