Rinatigen Duo Extended-Release Tablets 2.5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication should be taken once daily with dinner. The dosage of metformin hydrochloride should be gradually increased. To maintain extended-release characteristics, this medication should not be split, crushed, ground, or chewed but swallowed whole. Rinatigen 5/1000 mg extended-release tablets should be taken once daily, with one tablet per dose. Rinatigen 2.5/1000 mg extended-release tablets should be taken once daily, with two tablets being taken simultaneously. 1. Current

This medication is used for the treatment of type 2 diabetes and helps in controlling blood sugar levels. However, precautions must be strictly followed while taking this medication. First, this medication can rarely cause a serious condition known as lactic acidosis, which can lead to the excessive accumulation of lactic acid in the body, posing a dangerous condition requiring immediate treatment. Therefore, patients with moderate to severe kidney impairment, acute kidney injury, severe infections, or significant dehydration should not take this medication. Additionally, it is safer for patients with liver dysfunction, acute alcohol intoxication, or serious heart or respiratory diseases not to use this medication. Hypoglycemic symptoms may occur during the course of this medication, so care should be taken to monitor blood sugar changes, especially when taken with sulfonylureas or insulin. Acute pancreatitis or blistering skin diseases may also arise, so if severe abdominal pain or skin abnormalities occur during use, immediate consultation with a physician is necessary. This medication can lower vitamin B12 levels, so during long-term use, it is necessary to confirm vitamin B12 status through a blood test. Swallow the tablets whole without crushing, chewing, or breaking them, and it is normal for the tablet shell to pass in the stool. Furthermore, this medication may interact with other drugs, so if other medications are being taken, it is essential to inform your doctor or pharmacist. Women who are pregnant or breastfeeding should avoid this medication, and those planning a pregnancy should consult a doctor. Elderly patients may have decreased kidney function, so regular kidney function tests should be conducted, and dosage adjustments may be necessary. Finally, in case of overdose, immediate medical attention should be sought for appropriate treatment, and prompt action is needed, especially when symptoms of lactic acidosis occur. By adhering to these precautions and following the doctor’s instructions, the benefits of this medication can be safely enjoyed.

Serious side effects

Hives, severe swelling (angioedema), difficulty breathing, lactic acidosis, unusual liver function (abnormal liver function tests, hepatitis), pancreatitis, similar dermatitis, severe allergic reactions, severe skin reactions, respiratory issues, acute kidney injury, angioedema, angina, acute myocardial infarction, unstable angina, cardiac arrest, acute cholangitis, acute cholecystitis, cholangitis, acute pyelonephritis, sepsis, gallstones, kidney transplant failure, cerebral infarction, altered consciousness, vision changes

Mild side effects

Taste disturbances, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcers, itching, erythema, rash, severe and disabling joint pain, rhabdomyolysis, increased lipid-decomposing enzymes, increased amylase, nasopharyngitis, hypersensitivity reactions, angioedema, abnormal vitamin B12 absorption test results, abnormal liver function tests, hepatitis, similar dermatitis, increased serum triglycerides, increased urine albumin/creatinine ratio, decreased hemoglobin, serum potassium changes

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1°C and 30°C.

Appearance

Yellow oval extended-release film-coated tablet

Package unit

30 tablets/bottle