RinatiGen Duo Extended Release Tablets 5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

The 5/1000 mg extended-release tablet is taken once daily with one tablet per dose. Patients taking the 2.5/1000 mg extended-release tablet should take two tablets together once daily. The initial dosage is a total of 5 mg of linagliptin and 1000 mg of metformin hydrochloride per day, with the dosage of metformin hydrochloride gradually increased up to the maximum recommended dose of 2000 mg per day. Currently treated with metformin

This medication is mainly used to control blood sugar. It should not be administered to patients with impaired kidney function, and it is important to regularly test kidney function. Additionally, it is generally not safe to use this drug in cases of severe infection, dehydration, acute illness, or liver dysfunction. Since this drug can rarely cause a serious metabolic disorder known as lactic acidosis, immediate consultation with a doctor is necessary if symptoms such as abdominal pain, muscle pain, weakness, or shortness of breath occur. Since there may be symptoms of hypoglycemia, particularly when used in combination with sulfonylureas or insulin, blood sugar levels should be closely monitored. This medication should be taken during or after meals to reduce gastrointestinal disorders. Pregnant or breastfeeding women are advised to avoid this medication, and if planning a pregnancy, they should consult with their doctor. There could be rare side effects such as acute pancreatitis or bullous pemphigoid-like conditions when taking this medication, so if related symptoms occur, they must inform healthcare providers immediately. Vitamin B12 deficiency may occur, thus patients on long-term treatment should regularly check vitamin B12 levels in the blood. Additionally, this drug should not be chewed, crushed, or broken, but swallowed whole, and the coating of the tablet may be expelled in the stool. This medication can interact with other drugs, so patients should inform their doctor or pharmacist of any other medications they are taking. It may be necessary to temporarily stop this medication before surgery or radiological examinations, so follow the healthcare providers' instructions. Elderly patients are prone to decreased kidney function, so dosage adjustment and monitoring of kidney function are necessary. In case of overdose, the drug can be removed from the gastrointestinal tract, and if needed, it can be eliminated via hemodialysis, so it is crucial to visit the hospital immediately.

Serious side effects

Hives, angioedema, lactic acidosis, acute pancreatitis, bullous pemphigoid, liver function abnormalities (elevated liver function tests, hepatitis, acute cholangitis, acute cholecystitis, cholangitis), severe allergic reactions, angina pectoris, acute myocardial infarction, unstable angina, cardiac arrest, congestive heart failure, shortness of breath, asthma, pneumonia, acute kidney injury, end-stage renal disease, kidney transplant failure, severe and disabling joint pain, seizures, altered consciousness, acute cholangitis

Mild side effects

Taste disturbance, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcers, itching, erythema, rash, increased triglycerides in the blood, increased amylase, nasopharyngitis, allergic reactions, hypoglycemia (possible when used in combination), blood and lymphatic disorders, headache, dizziness, drowsiness, insomnia, depression, anxiety, vascular edema, vascular disorders, chest pain, fever, facial swelling, fatigue, dizziness, erectile dysfunction, benign prostatic hyperplasia

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The storage temperature should ideally maintain room temperature between 1 to 30 degrees Celsius.

Appearance

White oval extended-release film-coated tablet

Package unit

30 tablets/bottle