NARIGENTADUO Sustained Release Tablet 5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication is taken once daily with meals, preferably with dinner. The 5/1000 mg sustained release tablet is to be taken as 1 tablet daily. Patients taking the 2.5/1000 mg sustained release tablets should take 2 tablets simultaneously once daily. 1. If not currently treated with metformin: The initial dosage is a total of 5 mg of linagliptin and 1000 mg of metformin hydrochloride daily.

This medication is used to treat diabetes and helps control blood sugar levels. However, it can rarely cause a life-threatening condition called lactic acidosis, so caution is required. This medication should not be used if you have allergies to any of its ingredients, type 1 diabetes, severe kidney dysfunction, liver dysfunction, severe infections, or dehydration. It should also be avoided in cases of heart or respiratory diseases such as acute myocardial infarction, shock, or heart failure. Hypoglycemic symptoms may occur during treatment; therefore, careful monitoring of blood sugar changes is needed when used with other hypoglycemic agents. Elderly patients or those with unstable kidney function should have their kidney function regularly monitored, and dose adjustments may be necessary. This medication should be temporarily discontinued if acute kidney function deterioration is anticipated or when undergoing radiologic iodine contrast imaging tests. Swallow this medication whole without chewing or crushing; it may be seen in the stool but this is normal. If symptoms such as abdominal pain, severe muscle pain, weakness, or difficulty breathing occur, consult your doctor immediately. It is advisable to avoid using this medication during pregnancy or breastfeeding, and to consult a doctor if planning to become pregnant. This medication may lower vitamin B12 levels, so regular checks for vitamin B12 deficiency are necessary during prolonged use. Several drugs may interact with this medication; therefore, inform your doctor or pharmacist of any concurrent medications. In case of overdose, gastrointestinal disturbances and a risk of lactic acidosis may arise, so immediate medical treatment is essential. Lastly, keep this medication out of the reach of children and store it in a dry place.

Serious side effects

• Hives
• severe swelling (edema)
• angioedema
• lactic acidosis
• pancreatitis
• similar dermatitis
• pneumonia
• acute pyelonephritis
• sepsis
• asthma

Mild side effects

• Nasopharyngitis
• hypersensitivity reactions
• hypoglycemia
• taste disturbances
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The storage temperature should ideally be maintained at room temperature between 1 and 30 degrees Celsius. Proper storage will help ensure the safety and effectiveness of the medication.

Appearance

Oval sustained release tablet, white to nearly white, engraved with N501 on one side

Package unit

28 tablets/box (7 tablets/PTP x 4), 30 tablets/bottle