Linatap Duo Sustained Release Tablet 5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication is taken once daily with the evening meal. To maintain the sustained release formulation, do not crush, split, or chew the tablet, but swallow it whole. The 5/1000 mg sustained release tablet is taken once daily at a dose of 1 tablet. The 2.5/1000 mg sustained release tablet is taken once daily at a dose of 2 tablets simultaneously. 1. If not currently receiving treatment with metformin: The initial dose is a total daily dose of 5 mg of linagliptin.

This medication can cause a rare side effect known as severe lactic acidosis, so caution is required. It should not be used in patients with an allergy to any of its ingredients, type 1 diabetes, severely impaired kidney function, acute infections, or heart disease. There is a risk of hypoglycemia, so blood sugar levels should be closely monitored, especially when taken with insulin or sulfonylureas. Kidney function should be regularly tested, and this medication should not be taken if kidney function is low. Patients with unstable heart function or acute heart disease should also use this medication with care. When administering iodine contrast agents used during radiological examinations, the medication should be temporarily discontinued and can be resumed after kidney function has returned to normal. If surgery is planned, the medication should be stopped 48 hours prior to the surgery and resumed after kidney function has recovered post-surgery. This medication can cause severe pancreatic diseases such as pancreatitis, so if severe abdominal pain occurs, the doctor should be informed immediately. Vitamin B12 deficiency may occur, so it is advisable to regularly check blood levels of vitamin B12 if used for long durations. This medication should be swallowed whole and not crushed, chewed, or split, and while the tablet coating may be excreted in the stool, this is normal. This medication can interact with other drugs, especially those affecting the kidneys or blood sugar, so caution is recommended when taking them concurrently. It is advisable not to take this medication during pregnancy or breastfeeding, and those planning to become pregnant should consult a physician. Elderly patients may have decreased kidney function, so dosage adjustments and regular monitoring of kidney function are required. In case of overdose, there is a risk of lactic acidosis, and immediate medical treatment should be sought, which may require hemodialysis.

Serious side effects

Hives, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, severe rash with high fever, blistering, skin peeling, pain of mucous membranes of mouth/eyes, difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, dramatically decreased urine output.

Mild side effects

• Taste disturbance
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcers
• itching

This medication should be stored in a sealed container to prevent air or moisture from entering and kept at room temperature between 1 degree Celsius and 30 degrees Celsius. Proper storage helps maintain the medication's effectiveness and prevent degradation.

Appearance

White oval-shaped sustained release film-coated tablet

Package unit

30 tablets/bottle