Rinacomby Sustained-release Tablet 2.5/1000 mg (Linagliptin, Metformin)

Adult dose

This medication should be taken once daily with the evening meal. The 5/1000 mg sustained-release tablet should be taken as 1 tablet once daily. The 2.5/1000 mg sustained-release tablet should be taken as 2 tablets simultaneously once daily. To reduce side effects related to Metformin, any dosage increase should be gradual. 1. If not previously treated with Metformin: The total daily dosage should be Linagliptin 5 mg and Metformin Hydrochloride 1000 mg.

This medication contains Metformin and Linagliptin, which assist in blood sugar control. Care should be taken as this medication may rarely cause a serious metabolic complication known as lactic acidosis. Patients with severely impaired kidney function, those with acute disease states, patients with liver dysfunction, and those with acute alcohol intoxication should not take this medication. Additionally, those allergic to any components of this drug, patients with type 1 diabetes or diabetic ketoacidosis should not use it. This medication may cause hypoglycemia, hence it is important to closely monitor blood sugar changes when used in combination with sulfonylureas or insulin, and dose adjustments may be necessary. While taking this medication, do not skip meals to avoid low blood sugar, and avoid excessive exercise or alcohol consumption. Kidney function should be regularly monitored, and if kidney function declines, the use of this medication should be discontinued or adjusted. Prior to surgery or tests requiring radiation iodinated contrast agents, this medication should be temporarily discontinued, and usage should be resumed only after kidney function has returned to normal post-surgery. It is advisable to avoid using this medication during pregnancy, and it is recommended not to take it while breastfeeding. As it may reduce vitamin B12 levels, it is suggested to undergo regular vitamin B12 testing with prolonged use. This medication should be swallowed whole without breaking, chewing, or crushing the tablets, and it is normal for the tablet coating to be excreted in feces. Immediate medical consultation is required if sudden severe abdominal pain, persistent vomiting, muscle weakness, or difficulty breathing occurs during use. This medication may interact with other drugs, so patients must inform their doctor or pharmacist of any other medications they are taking. Elderly patients should take extra care as impaired kidney function is common, and regular kidney function tests are necessary. The impact of this medication on driving or operating machinery is unclear, yet awareness of hypoglycemia symptoms is advised. In the event of an overdose, the risk of lactic acidosis increases, necessitating an immediate hospital visit for treatment, and dialysis may be required. This medication should be stored out of reach of children, and kept away from moisture in its original container.

Serious side effects

Urticaria, severe swelling (angioedema), severe allergic reactions, severe skin reactions, difficulty breathing, respiratory distress, asthma attacks, pulmonary embolism, acute myocardial infarction, sepsis, liver abnormalities (hepatitis, liver function abnormalities, jaundice), serious neurological symptoms (acute pancreatitis, symptoms of acute pancreatitis, acute myocardial infarction, cardiac arrest, confusion, vision abnormalities, paralysis, cerebral infarction, subdural hematoma, hemiplegia, drowsiness, seizures)

Mild side effects

Hypoglycemia, taste disturbance, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcers, abnormal liver function, hepatitis, itching, erythema, rash, severe joint pain with disability, increased lipase, increased amylase, nasopharyngitis, hypersensitivity reactions, angioedema, abnormal vitamin B12 absorption test results, increased triglycerides in the blood, increased ALT, ear and labyrinth disturbances, anxiety, insomnia, depression, dizziness

This medication is sensitive to air and moisture, so it must be stored in a sealed container. It is important to maintain storage at room temperature between 1 and 30 degrees Celsius. This will help preserve the medication's effectiveness for a longer time.

Appearance

White oval sustained-release film-coated tablets engraved with AI 2.5/1000 on one side

Package unit

28 tablets (7 tablets/PTPX4)/box, 30 tablets/bottle, 100 tablets/bottle