Linaen Duo Extended Release Tablet 2.5/1000 mg (Linagliptin, Metformin)

Adult dose

For the extended-release tablet 5/1000 mg, take 1 tablet once daily. For patients taking the extended-release tablet 2.5/1000 mg, take 2 tablets at the same time once daily. If not currently being treated with metformin, the initial dosage is a total daily amount of 5 mg of Linagliptin and 1000 mg of metformin hydrochloride, and metformin hydrochloride can be gradually increased to the maximum recommended daily dosage of 2000 mg.

This medication may cause severe lactic acidosis and hypoglycemia, so caution is required. It should not be used by patients with allergy to the ingredients of this medication, type 1 diabetes, lactic acidosis, or diabetic ketoacidosis. It is also not to be administered to patients with severely impaired renal function or acute diseases that may affect renal function, such as dehydration, severe infections, or acute myocardial infarction. Patients with impaired liver function, acute alcohol intoxication, alcoholism, or malnutrition should also not take this medication. As this medication poses a risk of hypoglycemia, careful dosage adjustment is necessary when used with insulin or sulfonylureas. Regular checks of renal function are required, and if renal function declines, the medication should be discontinued or used cautiously. Skin conditions such as acute pancreatitis or similar bullous diseases may occur; symptoms should immediately be reported to a doctor. This medication may lower vitamin B12 levels, so it is recommended to monitor vitamin B12 levels during long-term use. When taking the tablet, do not crush or chew it; swallow it whole, even if the tablet's coating is excreted. There may be interactions with other medications, so caution is needed, especially when taking medications that affect renal function. It is advisable to avoid use during pregnancy or lactation and to consult a doctor if planning for pregnancy. Elderly patients often have reduced renal function, so dosages should be adjusted and renal function should be monitored regularly. In case of overdose, there is a risk of lactic acidosis, so immediate medical treatment should be sought, and dialysis may be necessary. When storing, keep in a sealed container out of children's reach and avoid moisture, and it is advisable not to transfer to other containers.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, similar bullous disease, severe allergic reactions, abnormal liver function (abnormal liver function, hepatitis, fatty liver), severe and disabling arthralgia, angioedema, headache, severe edema, dyspnea, heart failure, angina pectoris, acute myocardial infarction, unstable angina, cardiac arrest, acute kidney injury, end-stage renal disease, acute cholangitis, acute cholecystitis, cholangitis, cholelithiasis, asthma attacks, dyspnea, fever

Mild side effects

Hypoglycemia, taste disorders, cough, loss of appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcers, abnormal liver function, hepatitis, itching, erythema, rash, severe and disabling arthralgia, increase in lipase enzyme, increase in amylase, nasopharyngitis, hypersensitivity reactions, angioedema, abnormal vitamin B12 absorption test results, increase in blood triglycerides, increase in serum creatinine, increase in ALT, increase in AST, chest pain, fever, chills

This medication must be stored in a tightly sealed container to prevent exposure to air and moisture. It should be kept at room temperature, specifically between 1°C and 30°C, to maintain its effectiveness.

Appearance

Yellow, double convex, oval-shaped extended-release film-coated tablet

Package unit

30 tablets / bottle