Tralitin Combination Sustained-Release Tablet 2.5/1000 mg

Adult dose

This medication should be taken once daily with an evening meal. This sustained-release formulation of the drug 5/1000 mg is taken as a single tablet once daily. Patients taking this 2.5/750 mg or 2.5/1000 mg sustained-release formulation should take two tablets simultaneously, once daily. 1. For those not currently treated with metformin: the initial dosage is a total daily amount of 5 mg of linagliptin and metformin hydrochloride 1000 mg.

This medication can rarely cause serious lactic acidosis or hypoglycemia, so caution is required. It should not be used in patients with allergies to the active ingredients or components, in type 1 diabetes patients, or in certain patient groups with severely impaired renal function. This medication should not be administered in situations like dehydration, severe infections, or acute myocardial infarction, where the physical condition may rapidly deteriorate, nor in patients with impaired liver function. When used in conjunction with sulfonylureas or insulin, there is a risk of hypoglycemia, so it is important to carefully monitor blood sugar levels and adjust dosages of other medications as necessary. Lactic acidosis is very rare but can be fatal, so if symptoms such as abdominal pain, muscle weakness, or difficulty breathing occur, immediate medical attention should be sought. Since renal function plays an important role in the excretion of this medication, regular kidney function tests should be conducted before and during treatment, and discontinuation may be necessary if renal function declines. Patients with weak heart function should periodically check their heart and kidney function while using this medication. This medication should be temporarily discontinued before examinations that use radiological iodine contrast agents, and resumed only after confirming stable renal function post-examination. Patients scheduled for surgery should stop taking this medication 48 hours prior to surgery and resume only after confirming that renal function has recovered post-surgery. If acute pancreatitis or blistering skin disease is suspected, this medication should be discontinued immediately and medical personnel consulted. This medication may lower vitamin B12 levels, so long-term users should have blood tests to monitor vitamin B12 status and supplement as necessary. This medication should be swallowed whole, and while the tablet coating may be excreted, this is a normal occurrence. There may be interactions with other medications, so all medications being taken should be disclosed to medical personnel, especially caution is needed with drugs that can affect renal function. It is advisable to avoid using this medication during pregnancy or breastfeeding, and to consult with medical personnel if pregnancy is planned. Safety in children has not been established, and elderly patients should be carefully monitored due to the potential for decreased renal function. In case of overdose, gastrointestinal symptoms or lactic acidosis may occur, requiring immediate medical treatment. This medication should be kept out of reach of children and stored away from moisture and direct sunlight.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, lactic acidosis, pancreatitis, urticarial lesions, abnormal liver function (suspected liver abnormalities, jaundice), hepatitis, sudden and severe headache, angioedema, severe and disabling joint pain, acute kidney injury, acute cholangitis, acute cholecystitis, cholangitis, cholelithiasis, acute myocardial infarction, unstable angina, cardiac arrest, congestive heart failure, difficulty in breathing, asthma, seizure, unconsciousness.

Mild side effects

Altered taste, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcers, abnormal liver function, hepatitis, itching, erythema, rash, severe and disabling joint pain, rhabdomyolysis, increased lipase, increased amylase, nasopharyngitis, hypersensitivity, hypoglycemia (when combined with sulfonylureas), angioedema, urticarial lesions, abnormal vitamin B12 absorption test results, insomnia, depression, anxiety, dizziness, and fatigue.

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is recommended to maintain a storage temperature between 1 to 30 degrees Celsius to safely preserve its efficacy.

Appearance

Pink, double-convex, oval-shaped sustained-release film-coated tablet

Package unit

30 tablets/bottle