Medication info
GENUONE NisergoLine 30 mg

GENUONE NisergoLine 30 mg

Prescription medicationTabletOral
Ingredient · strength
Nicergoline›30mg / 1 tablet
Manufacturer / importer
GENUONE SCIENCE Co., Ltd.
Appearance
Yellow round film-coated tablet
Packaging
100 tablets/bottle, 30 tablets/bottle
Approval status
Active

MFDS item code 202400442 · Approved 2024.02.29 · Insurance code 671707410

Summary

Main use
Treatment of dementia syndrome (memory impairment, difficulty concentrating, etc.)
Who takes it
Adults
Adult dose
* 5 mg, 10 mg Adults: Administer 5 ∼ 10 mg of nicergoline orally before meals 2 ∼ 3 times daily. Adjust the dose appropriately according to symptoms. * 30 mg Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, the dose may be increased to 60 mg. The dose may be reduced after symptoms improve. In patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL), administer a reduced dose.

Ingredients

Manufacturer
GENUONE SCIENCE Co., Ltd.

Efficacy & effects

Treatment of dementia syndrome (memory impairment, difficulty concentrating, etc.)

  • Motivation decline
  • chronic cerebral circulation disorders
  • elderly atherosclerotic headaches
  • memory impairment
  • concentration disorder
  • judgment impairment
  • lack of initiative
View approved original text

This medication is used when motivation decline occurs due to chronic cerebral circulation disorders caused by the sequelae of cerebral infarction, and is also effective for atherosclerotic headaches commonly seen in the elderly. Additionally, it assists as an adjunct therapy for hypertension treatment. The 30 mg dosage is used for the treatment of key symptoms of primary degenerative vascular dementia and mixed dementia, such as memory impairment, concentration decline, judgment decline, and lack of initiative associated with dementia syndrome. This medication helps improve brain function and blood circulation, alleviating symptoms and contributing to the enhancement of quality of life. Overall, it supports brain and vascular health to improve patient symptoms.

How to take

Adult dose

* 5 mg, 10 mg Adults: Administer 5 ∼ 10 mg of nicergoline orally before meals 2 ∼ 3 times daily. Adjust the dose appropriately according to symptoms. * 30 mg Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, the dose may be increased to 60 mg. The dose may be reduced after symptoms improve. In patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL), administer a reduced dose.

Precautions

This medication should not be used in certain patients. For example, individuals allergic to this medication or ergot alkaloids, and those with acute myocardial infarction or acute bleeding should not be administered this. Moreover, individuals with very slow heart rates, those taking sympathomimetic agents, patients who have not achieved hemostasis after intracranial bleeding, and those with orthostatic dysregulation should also avoid using this drug. Patients with mild bradycardia or kidney function issues should use this medication cautiously. Side effects such as dyspepsia, diarrhea, constipation, nausea, vomiting, abdominal pain, dry mouth, etc., may rarely occur when taking this medication. Liver function test results may increase, and symptoms like dizziness, blood pressure changes, drowsiness, headache, fatigue, and insomnia may also infrequently occur. Allergic reactions such as skin rash or itching may appear, so caution is advised. When taken with other antihypertensives, blood pressure may drop too low, so blood pressure should be monitored frequently. It may affect uric acid levels, so patients with a history of gout should be especially careful. After taking, caution is required when driving or operating machinery. This medication is metabolized by specific enzymes in the liver, thus interactions may occur if taken with other drugs that utilize the same enzymes. Women who are pregnant or may become pregnant should carefully consider the benefits and risks of using this medication, and nursing mothers should avoid taking it or stop breastfeeding. Elderly individuals may have weakened physical functions, so caution in dosage reduction is advised. Safety for children has not been established, so it is best to avoid using this medication in pediatric patients. In case of overdose, blood pressure may drop, so close monitoring for blood pressure changes and appropriate measures may be needed. Finally, this medication should be stored out of reach of children and kept tightly closed in its original container. Transferring to a different container may reduce the quality of the medication or pose a risk of misuse.

Side effects

  • Loss of appetite
  • diarrhea
  • constipation
  • nausea
  • vomiting
  • diffuse upper abdominal pain or cramps
  • thirst
  • elevated ALT
  • elevated AST
  • dizziness
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  • orthostatic dysregulation
  • hypertension
  • increased blood uric acid
  • blood pressure decrease
  • drowsiness
  • fatigue
  • headache
  • tinnitus
  • fatigue
  • insomnia
  • rash
  • urticaria
  • itching
  • flushing
  • heat sensation
  • nightmares
  • mood disturbances
  • indigestion

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in an airtight container that prevents light exposure at room temperature between 1 degree and 30 degrees Celsius. By storing it this way, the effectiveness of the medication is well-maintained, and degradation is prevented.

Appearance and packaging

Appearance

Yellow round film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.