Serin Tablet 30 mg (Nisegoline)

Adult dose

* 5, 10mg Adults: Administer 5~10mg of nicergoline orally 2~3 times daily before meals. Adjust the dose as appropriate according to symptoms. * 30mg Adults: Administer 30 mg of nicergoline orally once daily before a meal. If the desired effect is not achieved at this dose, it may be increased to 60 mg. The dose may be reduced after symptoms improve. Reduce the dose in patients with impaired renal function (serum creatinine >175 µmol/L) (2 mg/dL).

This medication should not be used in specific patients. For example, patients allergic to this medication or ergot alkaloids, patients with acute myocardial infarction or acute bleeding, patients currently taking sympathomimetic drugs, patients with very slow heart rates, patients with unresolved intracranial bleeding, and patients with orthostatic control disorders should not take this medication. In addition, patients with mild bradycardia or renal function issues should take this medication with caution. Taking this medication may occasionally cause digestive symptoms such as dyspepsia, diarrhea, constipation, nausea, vomiting, abdominal pain, and dry mouth. Liver function test values may temporarily increase. Cardiovascular abnormalities such as dizziness, orthostatic hypotension, blood pressure changes, and increased blood uric acid have also been reported infrequently. Neurological symptoms such as drowsiness, fatigue, headache, and insomnia may also occur. Rarely, allergic reactions such as skin rash, itching, and flushing may occur. Since this medication has a blood pressure-lowering effect, regular blood pressure monitoring is necessary when taken with other antihypertensive medications to avoid excessive blood pressure reduction. Additionally, this medication may affect uric acid metabolism, so caution is advised for patients with a history of hyperuricemia or gout. Care should be taken when driving or operating machinery after taking this medication. This medication is metabolized by a specific enzyme (CYP450 2D6) in the liver, so interactions may occur if taken with other drugs that utilize this enzyme. Women who are pregnant or may become pregnant should use this medication with caution, as harmful effects on the fetus have been reported in animal studies. If breastfeeding, it is advisable to avoid use or discontinue breastfeeding if possible, as this medication may be excreted in breast milk. Elderly patients may have decreased physical function, so dosage should be adjusted when taking this medication. The safety for children has not yet been established. In cases of overdose, blood pressure may temporarily drop, so blood pressure changes should be monitored and necessary actions should be taken. Finally, this medication should be stored out of reach of children, and it is safest to keep it sealed in its original container.

• Loss of appetite
• diarrhea
• constipation
• nausea
• vomiting
• transient upper abdominal pain or cramps
• dry mouth
• ALT elevation
• AST elevation
• dizziness

This medication is sensitive to light and should be stored in a dark container that does not allow light. Additionally, it should be stored at room temperature, specifically between 1 to 30 degrees Celsius, to maintain its effectiveness.

Appearance

Yellow round film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle