Rinadiem Met Extended-Release Tablet 2.5/1000 mg (Linagliptin, Metformin)

Adult dose

This medication should be taken once daily with dinner. 5/1000 mg extended-release tablets are to be taken as 1 tablet once daily. Patients taking 2.5/1000 mg extended-release tablets should take 2 tablets at once once daily. The maximum recommended daily dose should not exceed Linagliptin 5 mg and extended-release Metformin Hydrochloride 2000 mg.

This medication may cause severe lactic acidosis or hypoglycemia, therefore caution is required. Individuals with an allergy to any of the ingredients or other components should not use this medication. It is not indicated for patients with type 1 diabetes, lactic acidosis, or diabetic ketoacidosis. Patients with severely impaired kidney function or in a state where acute kidney damage is anticipated should not use this medication. Administration should be avoided during acute illnesses affecting kidney function, such as dehydration, severe infections, severe injuries, or acute myocardial infarction. Patients with very poor cardiac function or severe pulmonary dysfunction should exercise caution when using this medication. Patients with liver dysfunction or severe gastrointestinal disorders should preferably avoid this medication. It should not be used in cases of acute or chronic alcohol intoxication. Administration should be avoided in patients with very poor nutritional status or states of starvation or frailty. Patients with acute and unstable heart failure, pregnant women at risk of placental insufficiency or pre-eclampsia, or those with a history of myocardial infarction should not use this medication. Due to the risk of hypoglycemia, careful dose adjustment is necessary, especially when used in combination with sulfonylureas or insulin. Although lactic acidosis is very rare, it is a serious complication that requires immediate consultation with a doctor in cases of worsening kidney function, cardiopulmonary disease, or sepsis. Regular monitoring of kidney function is recommended, especially for elderly patients or those with deteriorated kidney function. If iodinated contrast agents are used for imaging studies, it is necessary to discontinue this medication before and after the exam and check the kidney function status. It is advised to temporarily stop taking this medication for a certain period before and after surgery. If symptoms of acute pancreatitis or bullous skin disease occur, promptly inform a physician and discontinue this medication. Long-term use may lead to vitamin B12 deficiency; therefore, regular blood tests are recommended. This medication should be swallowed whole without chewing or crushing, and some tablet coatings may be excreted in the stool, which is normal. There may be interactions when taken with other medications, especially those affecting kidney function, so caution is necessary when used in combination. Use during pregnancy or breastfeeding is not recommended, and those planning to become pregnant should consult healthcare professionals. Safety for pediatric use has not been established, hence it should not be used in children. For the elderly, the possibility of kidney function decline is higher, thus starting at the lowest dosage and regularly checking kidney function is advised. In case of overdose, there is a risk of lactic acidosis, and immediate hospital treatment is required; hem dialysis may be necessary. Keep this medication out of the reach of children, and store it away from moisture.

Serious side effects

• Urticaria
• angioedema
• lactic acidosis
• liver function abnormalities
• hepatitis
• sudden and severe headache
• acute pancreatitis
• bullous dermatitis herpetiformis
• angioedema
• severe edema

Mild side effects

• Hypoglycemia
• taste disturbance
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcers

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

Yellow, double convex, oval extended-release film-coated tablet

Package unit

30 tablets/bottle