Hemopense Hemostatic (Thrombin)

Adult dosage

Thrombin should be mixed with sodium cross-linked hyaluronate gel in a prefilled syringe just before use. Important application steps: 1. Apply this medication directly to the site where bleeding has begun. 2. Carefully contact and secure this medication at the starting point of bleeding. 3. Use a sufficient amount to completely cover the damaged area of tissue. 4. Act promptly. 5. Ensure that the formed blood clot does not dislodge by always maintaining caution with the remaining amount of this medication.

This medication should not be administered intravenously or at sites of vascular occlusion, as coagulation in the blood vessel can lead to serious problems. It is used for hemostasis during surgery but should not replace common hemostatic methods. It should also not be used for preventive purposes. Do not use on infected areas, and if any signs of infection appear, additional surgery may be necessary. Contains components derived from cattle, which may occasionally cause serious adverse effects like coagulopathy, bleeding, or thrombosis. This medication is not suitable as a first-line treatment for patients with coagulation disorders. To reduce the risk of allergic reactions or thromboembolic events, it should not be used directly on blood vessels or tissues. It should not be administered to patients receiving other coagulation enhancers or antifibrinolytics, such as aprotinin products. Do not use in patients with severe arterial bleeding or for the treatment of ocular surgery sites, postpartum hemorrhage, or excessive menstruation. If allergic to components derived from cattle, do not use this medication. Use cautiously in patients with severely impaired liver function or in pregnant women. Rarely, symptoms of shock such as breathing difficulties, cyanosis, or hypotension may occur during use, so careful monitoring is necessary. If symptoms of hypersensitivity such as rash, urticaria, or pruritus occur, discontinue use immediately. Various side effects such as pain, rash, infection, and bleeding may occur at the surgical site, necessitating medical observation. This medication is for single use only and is not to be re-sterilized. The injection site must be thoroughly cleaned to avoid contamination with denaturing substances like alcohol or iodine, and any excess medication must be meticulously removed. When used in closed tissue spaces, it should be approached slowly, considering the drug's expansion properties. Safety when used with antibiotics has not been established, so caution is advised. In specific surgical fields, the safety and effectiveness of this medication have not been sufficiently validated. When storing, keep it out of reach of children and use it as soon as possible after opening. Administer the medication carefully following medical guidance, and report any unusual symptoms immediately for appropriate action.

Serious side effects

• Urticaria
• severe swelling (edema)
• respiratory difficulties
• drop in blood pressure
• shock
• severe allergic reactions
• abnormal bleeding
• coagulation disorders
• thromboembolic events
• urticaria

Mild side effects

• Rash
• fever
• pruritus
• headache
• nausea
• vomiting
• constipation
• dyspepsia
• abdominal pain
• diarrhea

Store this medication in a tightly sealed container to prevent the ingress of air or moisture, ideally at room temperature between 1°C and 30°C. Proper storage will maintain the drug's effectiveness and prevent degradation.

Appearance

A colorless, transparent vial containing a white to light yellow freeze-dried powder, a colorless, transparent solvent vial containing a colorless, transparent liquid, and a colorless, transparent additive containing sodium cross-linked hyaluronate.

Package unit

1 kit/kit