Janumax M Tablet 50/500 mg (Sitagliptin Phosphate Hydrate, Metformin Hydrochloride)

Adult dose

This medication is typically taken twice a day with food, gradually increasing the dosage to minimize gastrointestinal side effects caused by metformin. 1. Patients not currently being treated with metformin: Starting dosage is 50/500 mg, taking 1 tablet twice a day, with an option to increase to 50/1000 mg twice a day. 2. Patients currently being treated with metformin: Sitagliptin 50 mg twice a day.

This medication consists of two components, each with specific precautions. Firstly, one of the components may cause hypersensitivity reactions. Such reactions can range from severe allergic responses to severe skin rashes or inflammation, so if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur after taking the medication, discontinue use immediately and consult a doctor. Secondly, this medication may cause pancreatitis, which is an inflammation of the pancreas. Symptoms such as abdominal pain, nausea, or vomiting should prompt immediate medical attention. Thirdly, the other component may cause severe lactic acidosis, a rare but life-threatening metabolic complication. Lactic acidosis occurs when lactate accumulates excessively in the body, presenting symptoms like muscle pain, weakness, difficulty breathing, and abdominal pain. If these symptoms arise, discontinue the medication and inform healthcare professionals immediately. Additionally, this medication should not be administered to patients with impaired kidney function, severe heart or liver issues, pregnant or breastfeeding women, and those with certain acute conditions. While taking this medication, be cautious of irregular or insufficient food intake, intense exercise, or concurrent use of other medications, as this may increase the risk of hypoglycemia or lactic acidosis. Regular checks of blood sugar, kidney function, liver function, and vitamin B12 levels should be conducted to ensure no abnormalities arise during treatment. Symptoms of hypoglycemia include dizziness, sweating, and severe hunger, and the risk of low blood sugar may increase when this medication is taken with other hypoglycemic agents, requiring possible dosage adjustments depending on the medications being used. Furthermore, this medication should be temporarily stopped before surgeries, and it should also be interrupted for a period before and after tests using iodinated contrast agents. Excessive alcohol consumption should be avoided during treatment as alcohol may increase the risk of side effects from this medication. Lastly, in case of an overdose, seek immediate medical assistance, as some components can be removed through dialysis. This medication should not be administered to children, particularly those under 18 years of age, as its safety and efficacy have not been established in this age group. In elderly patients, reduced kidney function may occur, necessitating more cautious management and regular monitoring during treatment.

Serious side effects

• Hives
• angioedema
• chest tightness
• difficulty breathing
• anaphylaxis
• severe swelling (edema)
• severe rash
• blisters
• skin peeling
• oral/ocular mucosal pain

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• nasopharyngitis
• headache
• hypoglycemia
• constipation
• muscle pain

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. The optimal storage temperature is between 1 degree and 30 degrees Celsius at room temperature.

Appearance

Light pink oval film-coated tablets

Package unit

30 tablets/bottle, 120 tablets/bottle