Janumax M Tablet 50/850 mg (Sitagliptin Phosphate Hydrate, Metformin Hydrochloride)

Adult dose

This medication is generally taken twice daily with food, and the dosage is gradually increased to reduce gastrointestinal adverse reactions associated with metformin. 1. For patients currently not treated with metformin: Take this medication 50/500 mg twice daily, one tablet each time, and may increase to 50/1000 mg twice daily, one tablet each time. 2. For patients currently treated with metformin:

This medication contains two components, sitagliptin and metformin, and is primarily used to help control blood sugar levels in patients with type 2 diabetes. First, the sitagliptin component can cause rare but serious allergic reactions; if symptoms such as rash, swelling, or difficulty breathing occur within three months of administration, the patient should immediately stop taking the medication and consult a doctor. Additionally, there have been reports of acute pancreatitis, which is inflammation of the pancreas, so if symptoms such as abdominal pain, nausea, or vomiting occur, medical attention should be sought immediately and drug administration should be stopped. The metformin component can cause a rare but life-threatening metabolic complication known as lactic acidosis, so it should not be administered to patients with impaired kidney function, liver dysfunction, dehydration, severe infection, or congestive heart failure. This medication should not be used in patients with moderate or severe kidney impairment, those with acute heart failure or myocardial infarction, type 1 diabetes patients, women who are pregnant or nursing, and should be temporarily discontinued before and after tests using radiocontrast iodine. During treatment, kidney function and blood vitamin B12 levels should be regularly monitored for abnormalities, and excessive alcohol consumption should be avoided. Furthermore, while taking this medication, irregular meals, vigorous exercise, and interactions with other medications can potentially lead to hypoglycemia; thus caution is recommended. Common side effects may include diarrhea, nausea, headaches, and upper respiratory infections, while rarely, severe joint pain or skin diseases and muscle pain may occur. If severe hypoglycemic symptoms or serious symptoms such as skin rash, difficulty breathing, or abdominal pain appear, the patient should seek medical attention immediately. This medication is not recommended for children under the age of 18, pregnant women, or breastfeeding females, and should be administered cautiously to the elderly with frequent monitoring of kidney function. Administration should be temporarily halted during surgery or if the physical condition is unstable due to serious infections, and resumed after improvement in condition. Lastly, this medication may interact with various drugs, so it is important to inform healthcare providers of any other medications being taken and to regularly review blood sugar control and side effect occurrence during treatment.

Serious side effects

Hives, severe swelling (edema), anaphylaxis, angioedema, chest tightness, difficulty breathing, clammy skin, pallor, severe rash with fever, blisters, skin peeling, oral/ocular mucous membrane pain, severe skin reactions (including Stevens-Johnson syndrome), jaundice (yellowing of skin or eyes), generalized fatigue, sudden and severe headache, lightning headaches, seizures, confusion, vision changes, paralysis, changes in urination

Mild side effects

Diarrhea, upper respiratory infection, headaches, nausea, vomiting, abdominal pain, nasopharyngitis, constipation, itching, muscle pain, limb pain, back pain, thrombocytopenia, muscle pain, pruritus, dizziness, decreased appetite, weight loss, decreased serum vitamin B12, vitamin B12 deficiency, hypoglycemia, severe joint pain accompanied by disability

Store this medication in an air-tight container, preferably at room temperature between 1 and 30 degrees Celsius. This method of storage helps maintain the effectiveness of the medication for a longer period.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/bottle, 120 tablets/bottle