Rinaglometh Extended Release Tablet 5/1000 mg (Rinaglipti, Metformin)

Adult dose

This medication should be taken once daily with meals, preferably with dinner. The extended-release tablet should be swallowed whole and not broken, crushed, ground, or chewed. For 5/1000 mg extended-release tablet, the dose is one tablet daily, while for 2.5/1000 mg extended-release tablet, the dose is two tablets daily, taken once. The initial dosage consists of 5 mg of rinaglipti and 1000 mg of metformin hydrochloride, with metformin hydrochloride gradually increased to a maximum of 2000 mg.

This medication can, rarely, cause a serious condition known as lactic acidosis; therefore, it should not be used in patients with renal impairment, acute infections, dehydration, or severe trauma. Patients who are allergic to any active ingredients of this medication, patients with type 1 diabetes, and those with severe hepatic impairment should also not receive this treatment. Caution should be exercised when used in combination with insulin or sulfonylureas due to the risk of hypoglycemia, and the dosage of those medications may need to be reduced if necessary. Renal function should be regularly monitored, especially in the elderly or those with declining renal function. Skin conditions such as acute pancreatitis or bullous pemphigoid may occur; thus, immediate consultation with a doctor is advised if severe abdominal pain or skin abnormalities arise during treatment. This medication should be swallowed whole, without breaking, crushing, grinding, or chewing, and the shell of the tablet may appear in the stool, which is normal. Additionally, vitamin B12 levels may decrease, so it's advisable to regularly check vitamin B12 status with long-term use. This medication may interact with other drugs, particularly those that affect renal function or blood glucose levels, so caution is required. It is recommended not to use this medication during pregnancy or while breastfeeding, and women planning for pregnancy should consult a physician. The safety and effectiveness of this medication in children have not been established, so its use in this population is not recommended. In case of overdose, there is a risk of lactic acidosis; thus, immediate medical treatment should be sought. Store this medication out of reach of children and avoid humidity.

Serious side effects

• Urticaria
• angioedema
• lactic acidosis
• pancreatitis
• bullous pemphigoid
• liver function abnormalities
• hepatitis
• angioedema
• severe and debilitating arthralgia
• acute pancreatitis

Mild side effects

• Pharyngitis
• taste disorders
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcers

This medication is sensitive to air and humidity, so it should be stored in a closed container. Additionally, it should be kept at room temperature between 1°C and 30°C, avoiding extreme heat or cold.

Appearance

White oval extended-release film-coated tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle