Ritamezin Sustained Release Tablet 2.5/1000 mg (Linagliptin (Unmodified), Metformin Hydrochloride)

Adult dose

This medication is taken once daily with food, preferably with the evening meal. To maintain its sustained-release properties, it should not be divided, crushed, ground, or chewed, but swallowed whole. This sustained-release tablet 5/1000 mg should be taken once daily, with a single tablet per dose. For patients taking this sustained-release tablet 2.5/1000 mg, the dosage is two tablets taken once daily simultaneously. If the patient is not currently being treated with metformin,

This medication can rarely cause severe lactic acidosis or hypoglycemia, so if these symptoms occur, immediate medical consultation should be sought. Do not use this medication if you have allergies to any of its components, or if you have type 1 diabetes, lactic acidosis, diabetic ketoacidosis, severe renal impairment, acute myocardial infarction, or certain diseases. Patients with decreased kidney function should have their kidney function tested before administering this medication and should be monitored regularly for kidney function. When used in combination with sulfonylureas or insulin, the risk of hypoglycemia may increase, so blood sugar levels should be closely monitored. In the case of acute illness or before and after surgery, the use of this medication should be temporarily discontinued and can be resumed after kidney function has returned to normal. This medication may cause gastrointestinal upset, abdominal pain, diarrhea, nausea, etc., so it is advisable to take it during or after meals. If acute pancreatitis or symptoms suggestive of a bullous skin disease occur during taking the medication, stop immediately and consult with a healthcare professional. Long-term use may lead to vitamin B12 deficiency, so if symptoms of anemia or neurological symptoms occur, vitamin B12 levels should be checked. It is recommended to avoid using this medication during pregnancy or breastfeeding, and to consult a doctor if planning a pregnancy. This medication may interact with other drugs, so inform your healthcare provider about any other medications being taken. Elderly patients may have a potential decrease in kidney function, so dose adjustments and regular kidney function tests are necessary. This medication should not be chewed or crushed, and should be swallowed whole; the tablet coating may pass in the stool, which is normal. Keep out of reach of children and store away from moisture.

Serious side effects

Hives, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, liver dysfunction (abnormal liver function tests, hepatitis, jaundice), angina, acute myocardial infarction, unstable angina, cardiac arrest, dyspnea, asthma, pulmonary embolism, acute cholangitis, acute cholecystitis, cholangitis, cholelithiasis, acute renal failure, acute kidney injury, transplant failure, severe and disabling arthralgia, acute pancreatitis, pemphigus, acute alcohol intoxication, shock, sepsis

Mild side effects

• Taste disturbance
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcer
• itching

This medication should be stored in a tightly closed container to protect it from air and moisture. It is best to maintain a storage temperature between 1°C and 30°C at room temperature. This will help preserve the medication's effectiveness and safety.

Appearance

Yellow oval-shaped sustained-release film-coated tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle