Trachieduo Extended Release Tablet 2.5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication should be taken once daily with the evening meal. The 5/1000 mg extended-release tablet is taken once daily, 1 tablet at a time. The 2.5/1000 mg extended-release tablet is taken once daily, 2 tablets at a time. The initial dosage is linagliptin 5 mg and metformin hydrochloride 1000 mg, and metformin hydrochloride can be gradually increased to a maximum of 2000 mg per day.

This medication helps regulate blood sugar levels. However, it can rarely cause a serious metabolic complication called lactic acidosis, so caution is necessary. Lactic acidosis occurs when lactate accumulates excessively in the body, requiring immediate treatment; it can be life-threatening in severe cases. This medication should not be used in patients with specific conditions, such as type 1 diabetes, severe renal impairment, liver dysfunction, or in those with acute infections or dehydration. Furthermore, it should not be administered in cases of acute alcohol intoxication or alcoholism. This medication can cause hypoglycemia, so dosage adjustments may be necessary when used in conjunction with other hypoglycemic agents, such as insulin or sulfonylureas. If symptoms such as abdominal pain, muscle weakness, or difficulty breathing occur during treatment, consult a doctor immediately. Regular kidney function tests are important to ensure the medication's safety, and it should not be used if renal function is impaired. Temporary cessation of medication may be required in situations affecting kidney function, such as surgery or radiology tests. Rarely, side effects such as acute pancreatitis or bullous pemphigoid may occur during the use of this medication, and medical personnel should be informed of any suspicious symptoms immediately. Long-term use may lead to vitamin B12 deficiency, so regular monitoring may be needed. The tablets should not be chewed, crushed, or split, and they may pass through the stool intact, which is normal. This medication can interact with other drugs, so be sure to inform your doctor or pharmacist of any other medications you are taking. Pregnant or breastfeeding women should avoid using this medication and consult about safe alternative treatments. Elderly patients should take special care, as impaired kidney function is common, and regular kidney function tests should be conducted. In cases of overdose, the risk of lactic acidosis increases, so immediate treatment at a medical facility is required, and dialysis may be necessary. This medication should be kept out of reach of children and stored away from moisture.

Serious side effects

• Urticaria
• angioedema
• lactic acidosis
• pancreatitis
• bullous pemphigoid
• angioedema
• abnormal liver function
• hepatitis
• erythema
• angina

Mild side effects

• Nasopharyngitis
• taste disturbances
• cough
• reduced appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcer

This medication must be stored in a tightly closed container to protect it from air and moisture. Additionally, it is important to store the medication at room temperature, between 1 and 30 degrees Celsius, as extremes of temperature may affect its efficacy.

Appearance

Yellow oval-shaped extended-release film-coated tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle