Nesina Act Tablet 25/15mg (Alogliptin Benzoate, Pioglitazone Hydrochloride)

Adult dosage

This medication is taken once a day, regardless of meals. The tablet should not be divided. The recommended starting dose is 25mg/15mg which can be increased to a maximum of 25mg/30mg once daily based on blood sugar control response. For patients with renal impairment, no dose adjustment is needed for mild renal impairment (creatinine clearance ≥50 mL/min), and for moderate renal impairment (creatinine clearance 30~<50 mL/min) the dose is 12.5 mg/15 mg or 12.5 mg/30 mg once daily. This medication should not be given to patients with severe renal impairment or end-stage kidney disease. Dose adjustments may be necessary based on renal function, so periodic evaluation of renal function is recommended before starting and during treatment.

This medication is used for the treatment of type 2 diabetes. However, this medication can place a burden on the heart, and should not be used in patients with heart failure or a history of heart failure. Additionally, during the course of taking this medication, if symptoms of heart failure such as sudden weight gain, difficulty breathing, or edema appear, the healthcare provider should be informed immediately. This medication can affect liver function, so liver function tests should be performed before starting treatment, and if any symptoms of abnormal liver function appear during use, testing and consultation are needed immediately. This medication may increase the risk of bladder cancer, so patients with bladder cancer or a history of bladder cancer should not use it. This medication can cause hypoglycemia, so if taken with other hypoglycemic agents like insulin or sulfonylureas, blood sugar levels should be observed carefully. Edema or weight gain may occur; if these symptoms persist or worsen, consult with a healthcare provider. It is advisable for pregnant or potentially pregnant women, as well as breastfeeding women, to avoid using this medication. Special caution is needed for elderly patients, patients with impaired kidney function, and premenopausal women using this medication. If unusual reactions occur during treatment, such as skin rashes, hives, severe joint pain, or vesicular skin diseases, consult a doctor immediately. Finally, this medication must be taken according to a doctor's prescription and guidance. Additionally, all medications being taken should be reported to the healthcare provider due to potential drug interactions.

Serious side effects

Congestive heart failure, symptoms and signs of heart failure (including excessive and rapid weight change, dyspnea, edema), severe and disabling joint pain, anaphylaxis, angioedema, hives, severe skin reactions (such as severe rashes, blisters, skin peeling, mucosal pain in mouth/eyes), Stevens-Johnson syndrome, difficulty breathing, asthma exacerbation, jaundice, liver failure, severe neurological symptoms (such as headaches, seizures, confusion, vision abnormalities, paralysis)

Mild side effects

• Nasopharyngitis
• low back pain
• upper respiratory tract infection
• headache
• sinusitis
• muscle pain
• pharyngitis
• influenza
• hypoglycemia
• loss of appetite

This medication should be stored in a sealed container as it may be sensitive to air and moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius. Storing it this way will help preserve the medication's effectiveness and safety for a long duration.

Appearance

Yellow, round, biconvex film-coated tablet

Package unit

28 tablets/Alu-Alu[(14TX2ea)], 30 tablets/bottle, 100 tablets/bottle