PD Tablet 2mg (Methylprednisolone)

Adult dosage

The initial dose may vary from 4mg to 48mg of methylprednisolone per day, depending on the symptoms of the specific disease. For the treatment of acute exacerbations of multiple sclerosis, it is effective to administer prednisolone 200mg daily for 1 week, followed by prednisolone 80mg every other day for 1 month (4mg of methylprednisolone is equivalent to 5mg of prednisolone). Alternate-day therapy is a regimen in which twice the daily dose is given on one morning every other day. Although a single morning dose causes considerably less adrenal suppression than taking prednisolone (10mg) in 4 divided doses every 6 hours throughout the day, A regimen in which the initial suppressive dose is divided throughout the day The initial suppressive dose should be continued until a satisfactory clinical response is achieved, usually for 4 to 10 days in many allergic and collagen diseases. Switch to ADT and gradually reduce the amount of corticosteroid given every other day. As disease control permits, reduce the daily corticosteroid dose to the minimum effective dose as soon as possible, and then switch to an alternate-day schedule. It is preferable to administer 3 or even 4 times the daily dose every other day rather than twice the daily dose. If an acute exacerbation occurs during the course of the disease, it may be necessary to return to a fully suppressive corticosteroid dose divided throughout the day to achieve control.

This medication should not be administered to certain patients. For example, it should not be used in patients with hypersensitivity to this drug or any of its components, or in patients with infections without effective antimicrobial agents, such as herpes simplex, herpes zoster, or varicella. It is also contraindicated in patients receiving live vaccines or those with genetic issues like lactose intolerance. This drug should be used with caution in some patients. For example, patients with glaucoma, tuberculosis, cataracts, hypertension, thrombosis, heart disease, peptic ulcers, psychiatric disorders, osteoporosis, diabetes, renal failure, hypothyroidism, fatty liver, myasthenia gravis, elderly patients, epilepsy, and ulcerative colitis should pay special attention when using this drug. This medication can cause various side effects, including edema, increased blood pressure, muscle weakness, osteoporosis, gastrointestinal discomfort, skin changes, psychiatric and neurological symptoms, endocrine abnormalities, and eye-related issues, so it is important to closely observe symptoms during use and seek appropriate measures in case of abnormalities. Long-term use can lead to adrenal insufficiency, and sudden discontinuation can be dangerous, so it should be tapered off gradually. During trauma, surgery, or infection, the dosage may need to be temporarily increased. Due to immunosuppressive effects, the risk of infection is increased, so care should be taken to avoid exposure to varicella or measles, and prompt treatment is required if an infection occurs. This medication can interact with various drugs, so if other medications are being taken, patients must inform their healthcare provider, especially when used with heart-related medications, antibiotics, diuretics, or hypoglycemic agents. During pregnancy, this medication may affect the fetus, so it should be used only when absolutely necessary, and it should be avoided during breastfeeding. In pediatric patients, there is a risk of growth inhibition, so it should be administered at the minimum dosage with caution, and elderly patients are also at increased risk for side effects, so caution is needed. Finally, because this medication suppresses immune function, special attention should be paid to infection prevention and management, and care should also be taken during skin tests or vaccination.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkaline blood syndrome, congestive heart failure, hypertension, myasthenia, aseptic necrosis of the femoral and humeral epiphysis, steroid myopathy, muscle wasting, pathological fractures of the pelvis, osteoporosis, vertebral compression fracture, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, thirst, vomiting, stomachache, loss of appetite, increased appetite, peptic ulcer, abdominal distention, pancreatitis, esophagitis, diarrhea, wound healing delay, facial erythema, thin and fragile skin, abnormal sweating, petechiae, purpura, suppression phenomena of skin reactions, purpura, acne, hirsutism, alopecia, pigmentation, papilledema, increased intracranial pressure, seizures, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, growth suppression in children, symptoms of latent diabetes, secondary adrenal insufficiency, pituitary non-responsiveness, decreased glucose tolerance, increased requirement for insulin or oral hypoglycemics, suppression of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, posterior subcapsular cataract, secondary infection, retinal disorders, exophthalmos, negative nitrogen balance due to protein catabolism, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication should be stored in a tightly closed container to prevent air or moisture from entering, and it is recommended to store it at room temperature between 1°C and 30°C. Storing it this way helps maintain the medication's effectiveness and ensures safe use.

Appearance

White round tablet

Package unit

30 tablets/bottle, 300 tablets/bottle