Rabeprazole Sodium and Sodium Bicarbonate Tablet 10/400 mg (Rabeprazole, Sodium Bicarbonate)

Adult dosage

Gastric ulcers, duodenal ulcers: may administer 20/800mg (2 tablets) orally once daily according to symptoms. Usually given for up to 8 weeks for gastric ulcers and up to 6 weeks for duodenal ulcers. Erosive or ulcerative gastroesophageal reflux disease: administer 20/800mg (2 tablets) orally once daily for 4 to 8 weeks. If the condition does not improve after 8 weeks of proton pump inhibitors (PPIs), an additional 20/800mg (2 tablets) orally twice daily for another 8 weeks may be administered. However, this twice daily dosing is only for patients confirmed with severe mucosal damage. Long-term maintenance therapy for gastroesophageal reflux disease: administer 20/800mg (2 tablets) orally once daily, according to patient condition. ◯ Patients with liver dysfunction Adverse reactions have been reported in patients with liver cirrhosis and hepatic encephalopathy, so it should be administered with caution. ◯ Children Safety in children has not been established. ◯ The elderly Caution is required due to frequently reduced liver function.

Children's dosage

Safety in children has not been established.

This medication should not be used in patients with allergies to specific components or those taking certain medications such as Atazanavir or Lopinavir, and should not be used by pregnant or breastfeeding women. Patients with liver or kidney issues, the elderly, patients with cardiac or pulmonary conditions, and those with severe gastrointestinal ulcers should use this medication with caution. This medication may cause a variety of side effects including skin rash, itching, blood disorders, liver function abnormalities, cardiovascular issues, gastrointestinal symptoms, neurological symptoms, respiratory symptoms, muscle and joint pain, skin disorders, eye problems, and urinary system issues, so immediate consultation with a healthcare provider is advised if symptoms occur. This medication suppresses gastric acid secretion, which may slightly increase the risk of bacterial overgrowth in the stomach. Regular check-ups are needed, especially with long-term use. Long-term use may increase the risk of fracture, hypomagnesemia, vitamin B12 malabsorption, so caution is advised. It may cause drowsiness while driving or operating machinery; therefore, careful attention is needed. There may be interactions with certain medications, thus consultation with a healthcare provider is necessary if taken with Warfarin, Methotrexate, Atazanavir, Lopinavir, etc. Pregnant or breastfeeding women should not use this medication, and the elderly should use it cautiously due to potential side effects from reduced liver function. Safety in children has not been established, and there is limited experience using it in this population. In cases of overdose, there is no specific antidote; treatment according to symptoms and supportive therapy is necessary. This medication should be swallowed whole and should not be chewed or crushed, and must be kept out of reach of children. Long-term use may increase the risk of gastric polyps; thus, the minimum effective dose and duration of therapy is recommended. Kidney-related side effects such as acute interstitial nephritis may occur, so if there are any abnormal symptoms, stop and consult a healthcare provider immediately.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, high fever, severe rash, blisters, skin peeling, pain in mouth/eye mucosa, shortness of breath or difficulty breathing, asthma attacks, cough with fever and respiratory abnormalities, jaundice, profound lethargy, sudden severe headache, lightning headache, seizures, consciousness disturbance, visual abnormalities, paralysis, significantly reduced urine output,

Mild side effects

• Rash
• itching
• decreased red blood cells
• decreased white blood cells
• increased white blood cells
• increased eosinophils
• increased neutrophils
• decreased lymphocytes
• anemia
• petechiae

This medication should be stored in a tightly sealed container to prevent moisture and air exposure, at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the effectiveness and safety of the medication.

Appearance

White, round film-coated tablet

Package unit

100 tablets/box [10 tablets/PTP * 10EA]