Trafolmin Duo Sustained Release Tablets 5/1000 mg

Adult dose

For patients taking linagliptin 5 mg and metformin hydrochloride (sustained release) 1000 mg, administer 1 tablet once daily with meals. To reduce gastrointestinal side effects associated with metformin, it is recommended to take it in the evening with meals. To maintain the sustained-release properties, the tablet should not be split, crushed, ground, or chewed but swallowed whole. Dosage adjustments may be needed based on renal function.

This medication can rarely cause a dangerous condition called lactic acidosis, so if such symptoms occur, immediate medical attention is required. Do not take this medication if you are allergic to any of its components, have type 1 diabetes, lactic acidosis, diabetic ketoacidosis, severe renal impairment, severe liver dysfunction, acute alcohol intoxication, or are pregnant. Patients with impaired kidney function or poor heart and liver function should consult a physician before taking this medication. Due to the risk of hypoglycemia, caution is needed when taking this medication with other blood sugar-lowering agents like insulin or sulfonylureas, and dose adjustments may be needed if symptoms occur. This medication may lower vitamin B12 levels, so it is advisable to periodically check vitamin B12 levels during long-term use. Do not chew or crush the tablet; swallow it whole. The tablet shell may pass in the stool, which is normal. This medication may interact with several drugs that can affect kidney function, so it is important to inform your physician or pharmacist if you are taking other medications. It is safest to avoid using this medication during pregnancy or breastfeeding, and consult a physician if you plan to become pregnant. Elderly patients should undergo regular kidney function tests as kidney function may decline, and dosage adjustments may be necessary. If any unusual symptoms like acute pancreatitis or skin rash occur while taking this medication, inform your physician immediately. Skin conditions such as bullous pemphigoid may occur, so consult with healthcare providers if any skin abnormalities develop. This medication should be temporarily discontinued before and after surgery or radioactive iodine imaging tests and should only be resumed after kidney function has returned to normal. Overdose may result in severe side effects such as lactic acidosis, requiring immediate emergency treatment.

Serious side effects

• Hives
• angioedema
• lactic acidosis
• pancreatitis
• bullous pemphigoid
• acute cholangitis
• acute cholecystitis
• cholangitis
• acute kidney injury
• acute pyelonephritis

Mild side effects

Nasopharyngitis, taste disturbances, cough, loss of appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcers, itching, rash, increased lipase, increased amylase, abnormal absorption test results for vitamin B12, increased serum triglycerides, dizziness, fatigue, chest pain, fever, facial swelling, nosebleeds, oropharyngeal pain, voice disturbances, runny nose, wet cough, osteoarthritis, joint pain, musculoskeletal discomfort, myositis, muscle pain, hair loss, anxiety

Store this medication in a tightly closed container to prevent exposure to air and moisture. It is best to maintain the storage temperature between 1 to 30 degrees Celsius at room temperature.

Appearance

Pink, oval, biconvex, sustained-release film-coated tablet

Package unit

30 tablets/bottle