Zadim Duo Tablet 12.5/850 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage for this medication is 1 tablet once, twice daily. The dosage should be determined based on each patient's current treatment regimen, efficacy, and tolerance, staying within the maximum recommended daily doses of empagliflozin 25 mg and metformin 2000 mg for each component. For patients who cannot achieve sufficient blood sugar control with metformin alone or in combination with other medications such as insulin, the recommended dosage is empagliflozin.

This medication is used to treat diabetes and helps in controlling blood sugar levels. It should not be administered to patients with impaired kidney function or those with severe infections or dehydration. It is safest for pregnant or breastfeeding women to avoid this medication. Hypoglycemia may occur during treatment; caution is needed when taking alongside insulin or other blood sugar-lowering agents. Additionally, this medication can rarely cause a serious metabolic disturbance called lactic acidosis, so if symptoms such as sudden muscle pain, difficulty breathing, or weakness occur, contact a doctor immediately. There is a risk of urinary tract infections or genital infections, so appropriate treatment should be received if infection symptoms appear. If surgery is planned or if undergoing procedures using radiographic contrast agents, this medication should be discontinued for a period of time, and it should be resumed only after verifying normal kidney function. Elderly patients or those with compromised kidney function should regularly monitor kidney function and adjust the dosage accordingly. It is advisable to avoid alcohol during treatment and to use this medication with caution in situations where there is a risk of fluid loss. This medication may lower Vitamin B12 levels; thus, routine blood tests to check vitamin levels are recommended during long-term use. Moreover, various side effects may occur; if any unusual symptoms arise, consult a healthcare professional immediately.

Serious side effects

Severe lactic acidosis, severe hypoglycemia, severe allergic reactions (hives, angioedema), severe skin adverse reactions (severe rash, blisters, etc.), respiratory issues (asthma attacks, difficulty breathing, breathing abnormalities with cough + fever), liver abnormalities (jaundice), severe neurological symptoms (severe headache, seizures, confusion, vision changes, paralysis), severe edema or urinary abnormalities (markedly decreased urine output, severe generalized edema, increased blood pressure)

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

Store this medication in a tightly closed container to prevent air and moisture exposure, at a temperature between 1 to 30 degrees Celsius. This way of storing will help maintain the effectiveness of the medication for a longer period.

Appearance

Pink-tinted, white, double-convex oval film-coated tablet

Package unit

60 tablets/box (10 tablets/PTP x 6), 10 tablets/box (10 tablets/PTP x 1), 60 tablets/bottle, 30 tablets/bottle