Jadiplozin M Tablet 12.5/500 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage of this medication is 1 tablet once, twice a day. The dosage should be determined based on each patient's current treatment regimen, efficacy, and tolerability, not exceeding empagliflozin 25 mg and metformin 2000 mg. For patients combining with metformin alone or other medications like insulin where sufficient blood sugar control is not achieved, the recommended dosage is to take 5 mg of empagliflozin twice a day (total 10 mg) alongside the patient's current metformin dosage. If good tolerability of 10 mg of empagliflozin necessitates additional blood sugar control, the dosage can be raised to 25 mg (total per day). For patients transitioning from the combination of empagliflozin (10 mg or 25 mg daily) with metformin, use the existing doses of empagliflozin and metformin. When taken with sulfonylureas or insulin, dose reduction for those agents may be considered to decrease the risk of hypoglycemia (refer to precautions 4. Adverse reactions and 6. Interactions). To reduce gastrointestinal side effects associated with metformin, this medication should be taken with meals. If a dose is missed, take it as soon as remembered; however, do not take double the dose at once, and skip the missed dose in such cases.

This medication is used for the treatment of diabetes and helps in controlling blood sugar. However, it may cause a rare side effect known as severe lactic acidosis, so patients with poor kidney function or liver issues should not use it. Additionally, there is a risk of hypoglycemia when used in conjunction with insulin or sulfonylureas, so caution is advised. The dosage of this medication may be limited based on kidney function, and it should be avoided in special circumstances like acute kidney injury, severe infections, dehydration, or heart failure. This medication should be temporarily discontinued before and after exams using iodine contrast agents and resumed only after kidney function has returned to normal. Pregnant or nursing women should not take this medication, nor is it recommended for children under 18 years of age. During the course of treatment, side effects such as fluid loss, low blood pressure, urinary infections, and genital infections may occur, so symptoms should be carefully monitored. Hypoglycemia symptoms may occur, so caution is needed with irregular meals or intense exercise. Also, this medication can lower vitamin B12 levels, necessitating regular blood tests. Alcohol intake may increase the risk of lactic acidosis, so it is advisable to avoid it while taking this medication. Those with planned surgeries or acute illnesses should also temporarily discontinue this medication. This medication may interact with other drugs, so patients taking other medications should consult with their healthcare provider. Elderly individuals are at risk for decreased kidney function, so dose adjustments and regular monitoring of kidney function are necessary. In case of overdose, blood dialysis may be required, so it is important to adhere to the prescribed dosage. Finally, store this medication out of the reach of children and keep it in its original container to maintain its quality.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions with high fever and rashes, blisters, peeling skin, pain in mouth/eye mucosa, severe skin reactions, difficulty breathing or shortness of breath, asthma attacks, respiratory difficulties with coughing and fever, jaundice (yellowing of skin or eyes), profound lethargy, liver dysfunction (jaundice), sudden and severe headaches

Mild side effects

• Hypoglycemia
• urinary tract infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

Store this medication in a tightly sealed container to prevent exposure to air and moisture. It is best to keep it at room temperature between 1°C and 30°C.

Appearance

Light brownish-purple, biconvex oval film-coated tablet

Package unit

30 tablets/bottle, 60 tablets/bottle, 10 tablets/box (10 tablets/PTP x 1), 60 tablets/box (10 tablets/PTP x 6)