DapaM Duo Sustained Release Tablet 5/500 mg

Adult dose

This drug is generally administered once daily with the evening meal. The maximum dosages are 10 mg of dapagliflozin and 2000 mg of sustained-release metformin once daily, dosed as 2 tablets of 5 mg/1000 mg. When used as initial therapy, the recommended starting dose is 5 mg/500 mg or 10 mg/500 mg once daily. To minimize gastrointestinal side effects of metformin, doses should be adjusted gradually.

This drug is an antidiabetic medication that helps in controlling blood sugar. It may very rarely cause a serious metabolic disorder called lactic acidosis, which can be life-threatening; therefore, caution is needed. When used in combination with other antidiabetic drugs, there is a risk of hypoglycemia, so blood sugar levels should be closely monitored. This drug should not be used in patients with significantly impaired kidney function, serious infection or dehydration, type 1 diabetes patients, pregnant or nursing women, etc. Patients undergoing surgery or those undergoing tests using iodine contrast agents should temporarily discontinue this drug and restart it after confirming normal kidney function. Elderly patients or those with compromised kidney function should regularly check kidney function and fluid status before and after taking this drug, and carefully observe for any symptoms of hypotension or dehydration. This drug may increase the risk of genital and urinary tract infections, so if infection symptoms appear, medical consultation should be sought immediately. The metformin component may lower vitamin B12 levels, thus checking vitamin B12 levels regularly during long-term use is advisable. Excessive alcohol consumption should be avoided, and it is preferable to limit alcohol intake during treatment. This drug may need to be temporarily discontinued in situations of difficult blood sugar control, and dosage adjustments of insulin or other antidiabetic agents may be required to prevent hypoglycemia. Pregnant women or women who may become pregnant should avoid taking this drug, and it is also best for nursing mothers not to use it. There may be risks of dizziness or hypoglycemia when driving or operating machinery while taking this drug, so caution is advised. Keep out of reach of children and store in the original container to prevent misuse or degradation of quality.

Serious side effects

Severe lactic acidosis, severe hypoglycemia, renal dysfunction, acute kidney injury, lactic acidosis-related hepatic abnormalities, ketoacidosis, urosepsis, pyelonephritis, severe allergic reactions, severe edema, perineal necrosis

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia (when used with sulfonylureas or insulin), dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, vulvar pruritus, genital pruritus, dyslipidemia, increase in serum creatinine, increase in serum urea, weight loss, chest pain, weakness, fatigue, peripheral edema, swelling, pain, hyperglycemia, urethral syndrome,

This drug should be stored in a tightly closed container to avoid exposure to air or moisture. Additionally, it is advisable to store the medication at room temperature between 1 degree and 30 degrees Celsius, avoiding very hot or very cold places.

Appearance

Orange rectangular sustained-release film-coated tablet

Package unit

28 tablets/box [7 tablets/PTP x 4]