A.D. Duo Tablet 12.5/1000 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage of this medication is 1 tablet, twice daily. The maximum recommended daily dose for each component is 25 mg of empagliflozin and 2000 mg of metformin. If blood sugar control is insufficient, 5 mg of empagliflozin may be taken twice daily, and if tolerability is excellent, the dose may be increased to 10 mg or a maximum of 25 mg. This medication should be taken with meals, and if a dose is missed, it should be taken as soon as remembered.

This medication may cause serious side effects such as severe lactic acidosis, and caution is advised. It is contraindicated in patients with significantly reduced kidney function or those at risk of acute kidney injury. Additionally, there is a risk of hypoglycemia when used in combination with insulin or sulfonylureas. Prior to taking this medication, patients should inform their healthcare provider if they have a history of allergic reactions, liver dysfunction, heart failure, severe infections, or pending surgery. When undergoing tests involving iodine contrast agents, this medication should be discontinued for a period before and after the examination, and it should only be restarted once kidney function has been confirmed as normal. Pregnant women, women who may become pregnant, and nursing mothers should not take this medication, and elderly patients or those with reduced kidney function may require dose adjustments and monitoring of kidney function. This medication may increase the risk of urinary tract infections and genitourinary infections; therefore, if infection symptoms occur, consult a physician immediately. Long-term use may lead to vitamin B12 deficiency; therefore, regular blood tests are recommended. In case of overdose, serious side effects such as lactic acidosis may occur, and patients should visit a medical institution immediately; dialysis may be required. It is important to avoid alcohol consumption while taking this medication. Lastly, care should be taken regarding fluid loss or dehydration, and if such symptoms occur, the medication should be temporarily discontinued and medical advice should be sought.

Serious side effects

Hives, severe swelling (edema), angioedema, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in mouth/eyes mucosa, shortness of breath or difficulty breathing, asthma attacks, cough with fever respiratory abnormalities, yellowing of skin or eyes (jaundice), extreme fatigue, sudden and severe headaches, thunderclap headaches, seizures, confusion, visual disturbances.

Mild side effects

• Nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation
• itching
• rash
• hives
• erythema

Store this medication in a tightly closed container to protect it from air and moisture, at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness over time.

Appearance

Biconvex oval film-coated tablet with a dark brownish purple color

Package unit

60 tablets/box [10 tablets/PTP X 6], 10 tablets/box [10 tablets/PTP X 1], 60 tablets/bottle