Coxduo Tablet

Adult dose

Adults: Take 1 tablet twice daily. This medicine may be taken with or without food. Take this medicine whole; do not crush or split it. ○ Patients with hepatic impairment This medicine is not recommended for initial treatment in patients with hepatic impairment who require a dose reduction (see Precautions for Use, 5. General Precautions)

This drug may pose a risk of gastrointestinal bleeding in individuals who regularly consume three or more alcoholic beverages daily; thus, consultation with a doctor or pharmacist is essential. This drug may increase the risk of cardiovascular diseases, potentially leading to serious cardiovascular issues such as myocardial infarction or stroke; therefore, it should only be used at the minimal dosage and duration necessary. Serious complications such as gastrointestinal perforation, ulcers, and bleeding may arise; individuals with a history of gastrointestinal diseases or the elderly should take this medication with extra caution. This drug is contraindicated for those with specific allergies or hypersensitivity, severe heart, liver, or kidney diseases, active peptic ulcer, as well as pregnant or nursing women. Patients with reduced liver or kidney function, asthma, hypertension, or heart failure should take extra precautions while using this medication and undergo regular examinations as advised by their doctor. During treatment, side effects such as headaches, indigestion, abdominal pain, skin rashes, swelling, and hypertension may occur; if symptoms are severe, immediate consultation with medical personnel is necessary. This drug can interact with other medications; therefore, if you are currently taking any other medicines, it is essential to inform your healthcare provider, especially when combining with antihypertensives, anticoagulants, diuretics, antidepressants, etc. Women who are pregnant or planning to become pregnant should not take this medication, and if pregnancy is confirmed while taking it, they should stop immediately and consult their doctor. Elderly patients are likely at increased risk for reduced kidney and liver function; hence, careful observation and management are necessary when using this medication. Regular blood tests, liver function tests, and kidney function tests should be conducted during therapy to check for abnormalities; if any signs are detected, the medication should be stopped immediately. Dizziness or drowsiness may occur after taking this medication; thus, caution is advised when driving or operating machinery. In case of overdose, symptoms such as nausea, vomiting, and lethargy may appear; in such cases, immediate medical attention should be sought.

gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, upper and lower gastrointestinal perforation, ulcers, bleeding, dyspepsia, nausea, upper abdominal pain, constipation, diarrhea, dry mouth, esophageal pain, stomatitis, COVID-19, acute pyelonephritis, facial edema, pain at the insertion site, peripheral edema, fever, pruritus, psoriasis, rash, skin swelling, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated blood pressure, elevated blood uric acid, elevated gamma-glutamyl transferase, arthralgia, back pain, coccygodynia, flank pain, headache, carpal tunnel syndrome, lymphadenopathy, cholelithiasis, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, delirium, dizziness, muscle hypertonicity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, urticaria, angioedema, alopecia, blistering dermatitis, peripheral edema, facial edema, influenza-like illness, injury, vesicular dermatitis, petechiae, angioedema, alopecia, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, hepatic failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug eruption, acute generalized exanthematic pustulosis, folliculitis, contact dermatitis, injection site reaction, skin nodules, dysgeusia, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, elevated NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorders, insomnia, heartburn, dry mouth, nausea, diarrhea, malaise, hypertriglyceridemia, hypercholesterolemia, transaminitis, elevated ALT, elevated AST, itching, leukopenia, headache, upper respiratory tract infection, blurred vision, gastritis, gastroesophageal reflux, edema, loss of appetite, nausea, vomiting, diarrhea

This medication should be stored in a tightly closed container to avoid exposure to air or moisture. It is advisable to maintain storage temperatures between 1 to 30 degrees Celsius.

Appearance

Yellow rectangular film-coated tablet composed of two layers

Package unit

30 tablets/bottle, 300 tablets/bottle