Medication info

Anidipin S Tablet 1.25 mg (Esamlodipine Besylate Hydrate)

Prescription medicationTablet경구
Ingredient · strength
S-Amlodipine Besylate Dihydrate›1.844mg / 1 tablet
Manufacturer / importer
(주)종근당
Appearance
White or light yellow octagonal tablet
Packaging
Bottle - 30 tablets/bottle
Approval status
Active

MFDS item code 202302314 · Approved 2023.08.01

Summary

Main use
Improvement of myocardial ischemia caused by hypertension and coronary artery disease (angina) and reduction of the risk of hospitalization due to angina
Who takes it
Adults · Children
Adult dose
As esamlodipine, 2.5 mg is administered orally once daily, and may be increased to a maximum of 5 mg per day based on the patient's response. Adjustments should be made appropriately according to age and symptoms.
Child dose
The recommended oral dosing of esamlodipine for effective blood pressure reduction is 1.25 mg to 2.5 mg taken once daily. Doses exceeding 2.5 mg per day in pediatric patients have not been studied.

Ingredients

Manufacturer
(주)종근당

Efficacy & effects

Improvement of myocardial ischemia caused by hypertension and coronary artery disease (angina) and reduction of the risk of hospitalization due to angina

  • Hypertension
  • fixed occlusion of coronary arteries
  • vasospasm of coronary vessels
  • vascular contraction
  • myocardial ischemia
View approved original text

This medication is used in the treatment of myocardial ischemia caused by hypertension and stable and variant angina. It also helps to reduce the risk of hospitalization due to angina in patients who have recently been diagnosed with coronary artery disease through angiography but do not have heart failure and whose cardiac output is at a normal level. Moreover, it is effective in reducing the risks associated with coronary interventions. Therefore, it plays an important role in improving cardiovascular health and alleviating symptoms of angina.

How to take

Adult dose

As esamlodipine, 2.5 mg is administered orally once daily, and may be increased to a maximum of 5 mg per day based on the patient's response. Adjustments should be made appropriately according to age and symptoms.

Child dose

The recommended oral dosing of esamlodipine for effective blood pressure reduction is 1.25 mg to 2.5 mg taken once daily. Doses exceeding 2.5 mg per day in pediatric patients have not been studied.

Precautions

This medication should not be used by certain patients. For example, individuals who are allergic to this medication or its components, or to similar types of medications, should avoid taking it. Women who are pregnant or may become pregnant, as well as nursing mothers, should not use this medication. Patients in cardiogenic shock, those with severe aortic stenosis, unstable angina patients, and individuals within one month after a myocardial infarction should not take this medication. Additionally, patients with severe liver dysfunction or severe hypotension should also refrain from using it. Caution should be exercised when using this medication in patients with very poor kidney function, elderly patients, those with acute heart failure, patients in hypertensive crisis, and patients with mild to moderate liver dysfunction. Various side effects may occur when taking this medication. The most common side effects include flushing with a feeling of warmth, fatigue, swelling of the hands and feet, palpitations, dizziness, headache, nausea, dyspepsia, drowsiness, and ankle swelling. Occasionally, rarer side effects may include dry mouth or excessive sweating, significant hypotension, severe dizziness, sensory disturbances, erectile dysfunction, gastrointestinal issues, liver function abnormalities, skin rashes or allergic reactions, memory impairment, depression, difficulty breathing, and hair loss. If any unusual symptoms occur, immediate consultation with healthcare personnel is necessary. Abrupt discontinuation of this medication can worsen symptoms, so it is important to reduce the dosage gradually under medical supervision and not to stop taking it arbitrarily. It is advisable to take this medication with a sufficient amount of water, and caution should be exercised when driving or operating dangerous machinery due to potential dizziness or drowsiness caused by its blood pressure-lowering effects. This medication may interact with other drugs, so it is crucial to inform medical personnel of any concurrent use, especially with certain antibiotics, antihypertensives, antidepressants, heart medications, or grapefruit juice, as caution is required. If you are pregnant or breastfeeding, you should avoid taking this medication as its safety has not been established. If breastfeeding, it is recommended to discontinue breastfeeding. For children, use is recommended only for those aged 6 years and older, and in elderly patients, the effects and side effects may be more pronounced, so initiation should be at a lower dose with careful monitoring of their condition. In the case of overdose, severe hypotension, heart problems, shock, or decreased consciousness may occur, requiring immediate emergency treatment. This medication is not removed by dialysis, so special treatment is required. Finally, this medication should be kept out of reach of children, and transferring it to other containers may cause degradation of quality or incidents, so caution is advised.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, mucosal pain in the mouth/eyes, severe skin reactions, tightness in the chest or difficulty breathing, asthma attack, cough with fever accompanied breathing abnormalities, yellowing of the skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden and severe headaches, thunderclap headache,

Mild side effects

Flushing accompanied by a feeling of warmth, fatigue, swelling, palpitations, dizziness, headache, migraine, weakness, abdominal pain, nausea, dyspepsia, drowsiness, dry mouth, increased sweating, weakness, lethargy, pain, weight gain/loss, chills, hypotension, orthostatic hypotension, positional dizziness, peripheral ischemia, vasculitis, syncope, tachycardia, peripheral edema, increased muscle tension, sensory deficit/sensory disturbances, peripheral neuropathy, taste disturbances, tremors, paralysis, extrapyramidal disorders, erectile dysfunction,

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to protect it from air and moisture. The recommended storage temperature is room temperature between 1 degrees and 30 degrees Celsius. This will help maintain the medication's efficacy and safety for a longer period.

Appearance and packaging

Appearance

White or light yellow octagonal tablet

Package unit

Bottle - 30 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.