Januvia Tablets 100/15 mg (Sitagliptin, Pioglitazone)

Adult dosage

This drug can be administered to patients with type 2 diabetes taking sitagliptin 100 mg and pioglitazone 15 mg or 30 mg, at a dosage of 1 tablet once daily regardless of meals.

This drug contains sitagliptin and pioglitazone, and there are precautions to be taken depending on each ingredient. First, sitagliptin can rarely cause serious allergic reactions. Such reactions may include hives, skin rash, difficulty breathing, and swelling of the face or neck; if these symptoms occur, it is important to stop taking the drug immediately and consult a doctor. Additionally, sitagliptin can cause acute pancreatitis, a condition where inflammation occurs in the pancreas, so if abdominal pain, vomiting, or loss of appetite arise during use, immediate medical attention is required. Pioglitazone can burden the heart and should not be used in patients with heart failure or a history of heart failure. If sudden weight gain or symptoms of heart failure such as edema or shortness of breath occur during treatment, it is essential to promptly inform medical personnel. Moreover, pioglitazone can cause fluid retention and exacerbate edema, so it is necessary to regularly check weight and edema status due to possible weight gain. This drug should not be given to patients with a history of bladder cancer or those with active bladder cancer. If blood or pain occurs during urination, it is critical to inform a doctor quickly. Patients with severely impaired kidney function should not take this drug, and those with slightly decreased kidney function may require dose adjustment, necessitating regular kidney function tests. Women who are pregnant or may become pregnant should not take this drug, and premenopausal women should use appropriate contraception while taking this medication. During treatment, hypoglycemic symptoms may occur, so if symptoms such as dizziness, cold sweat, or severe fatigue arise, blood sugar levels should be checked and appropriately managed. Liver function abnormalities may occur while taking this medication, so if symptoms like fatigue, jaundice, or changes in urine color appear, prompt medical evaluation is necessary, and regular liver function tests are recommended. Some patients may experience arthralgia or skin disorders, so any new pain or skin changes should be reported to medical personnel. Finally, this drug may interact with other medications, so if other drugs are being taken, it is vital to inform medical personnel and to follow the doctor's instructions regarding administration.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, rash, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, difficulty breathing or shortness of breath, asthma attack, respiratory distress accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, markedly reduced urine output

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• myalgia
• limb pain
• back pain

This drug should be stored in a container that blocks light and air, and humidity should be avoided. A storage temperature between 15 and 30 degrees Celsius is appropriate.

Appearance

Light orange rectangular film-coated tablet

Package unit

28 tablets/box [14 tablets/PTP x 2]