Janumet 100/15 mg (Sitagliptin Phosphate, Pioglitazone Hydrochloride)

Adult dosage

This medication can be administered to patients with type 2 diabetes, combining sitagliptin 100 mg and pioglitazone 15 mg or 30 mg, as one tablet once daily regardless of meals.

This medication contains sitagliptin and pioglitazone, each with specific cautions to be aware of. First, the sitagliptin component may rarely cause serious allergic reactions. Symptoms such as severe skin swelling, rash, difficulty breathing, and anaphylaxis can occur, so if any of these symptoms appear, the medication should be stopped immediately, and a doctor should be consulted. Sitagliptin can also cause acute pancreatitis, an inflammation of the pancreas. Symptoms such as abdominal pain, nausea, and vomiting should prompt immediate medical attention. The pioglitazone component may strain the heart, so patients with existing heart failure or a history of heart failure should not take this medication. During treatment, symptoms of heart failure such as weight gain, swelling, and dyspnea may occur; if these symptoms arise, medical personnel should be notified immediately. This medication should not be given to patients with a history of bladder cancer or current bladder cancer. It should also be avoided by patients with severely impaired kidney or liver function. Women who are pregnant or may become pregnant should not take this medication. Pre-menopausal women should use appropriate contraception since this medication may promote ovulation. Patients should be vigilant for symptoms of hypoglycemia while using this medication, especially when combined with insulin or sulfonylureas, as the risk of hypoglycemia may increase. While taking this medication, if symptoms such as swelling, weight gain, joint pain, skin rash, or blisters occur, medical personnel should be informed immediately. If symptoms of liver dysfunction (fatigue, jaundice, loss of appetite, etc.) present, prompt testing is recommended. Additionally, this medication contains lactose and should not be prescribed for patients with lactose intolerance. Lastly, this medication may interact with other drugs, so if patients are taking any other medications, they must inform their doctor or pharmacist, and regular assessments of kidney and liver function are recommended.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, anaphylaxis, angioedema, Stevens-Johnson syndrome, severe skin adverse reactions, severe allergic reactions, angioedema, acute pancreatitis, fatal and non-fatal hemorrhagic pancreatitis, jaundice, liver anomalies (jaundice), severe neurological symptoms, severe edema or urinary problems, congestive heart failure, heart failure, pneumonia, cardiac arrest, diabetes complications, metabolic acidosis, acute renal failure.

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• nausea
• diarrhea
• abdominal pain
• constipation
• myalgia
• limb pain
• back pain

This medication should be stored in a special container that keeps out light and air, and must be kept away from humid areas. To maintain its effectiveness, it is best stored at temperatures between 15 and 30 degrees Celsius.

Appearance

Light orange film-coated tablets in an oblong shape

Package unit

28 tablets/box [14 tablets/PTP x 2]