Dapagliflozin Propanediol Hydrate / Sitagliptin Phosphate Hydrate / Metformin Hydrochloride Colloidal Silicon Dioxide Extended-Release Tablet 5/50/1000 mg

Adult dose

This medication should be taken once daily in the evening with meals to reduce gastrointestinal side effects caused by metformin hydrochloride. Patients taking the 10/100/1000 mg extended-release tablet should take 1 tablet once daily. Patients taking the 5/50/500 mg, 5/50/750 mg, and 5/50/1000 mg extended-release tablets should take 2 tablets once daily. Extended-release metformin

This medication contains sitagliptin, dapagliflozin, and metformin components and is used for diabetes treatment. Firstly, the sitagliptin component can rarely cause serious allergic reactions such as anaphylaxis or skin disorders, so if any abnormal symptoms arise, you should consult a doctor immediately. Also, acute pancreatitis may occur, so symptoms such as abdominal pain should be closely monitored, and if pancreatitis is suspected, the medication should be discontinued. Next, the dapagliflozin component works by increasing the excretion of glucose through urine, lowering blood glucose levels. This may increase the risk of genital and urinary tract infections, so appropriate treatment is necessary if infection symptoms occur. Additionally, hypotension or renal impairment may occur due to decreased fluid volume; therefore, caution should be exercised, especially in individuals with reduced renal function or the elderly. In severe cases, serious infections such as necrotizing fasciitis may occur, so immediate treatment is required if related symptoms appear. If blood glucose control is inadequate, a metabolic disorder called ketoacidosis may develop; hence, symptoms such as vomiting, abdominal pain, and difficulty breathing should be closely monitored. The metformin component poses a risk of lactic acidosis, a rare but fatal metabolic complication in patients with impaired liver and kidney function, necessitating regular renal function tests. It also carries the risk of gastrointestinal disorders, vitamin B12 deficiency, and hypoglycemia, particularly when used in conjunction with other hypoglycemic agents or alcohol. This medication should not be administered to patients with severely impaired renal function, acute heart failure, acute myocardial infarction, severe liver disease, or pregnant women. Moreover, patients scheduled for surgery or those with severe infections should temporarily discontinue the medication. During use, symptoms of hypoglycemia, infection, abdominal pain, skin rash, and reduced fluid volume should be monitored closely, and if any abnormalities occur, immediate consultation with medical personnel is essential. Regular tests of kidney and liver function should be conducted, and particularly elderly patients or those with impaired renal function require closer monitoring.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, severe allergic reactions, severe skin abnormal reactions, difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities accompanied by coughing and fever, yellowing of skin or eyes (jaundice), extreme malaise, liver abnormalities (jaundice), sudden and terrible

Mild side effects

• Hypoglycemia
• headache
• nausea
• diarrhea
• constipation
• dry mouth
• muscle pain
• lower back pain
• dysuria
• polyuria

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best to maintain a temperature between 1 and 30 degrees Celsius.

Appearance

Yellow, biconvex, oval-shaped extended-release film-coated tablet

Package unit

30 tablets/bottle